Results 81 to 90 of about 5,219,314 (384)

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Preoperative coping mechanisms have no predictive value for postoperative pain in breast cancer

Brazilian Journal of Psychiatry, 2013
Objective: This study evaluated the relationship between psychological coping mechanisms and symptoms of anxiety and depression in the preoperative and postoperative periods in relation to the intensity of postoperative pain among patients undergoing ...
Maria Luiza Alves, Joaquim Edson Vieira, Lígia Andrade Silva Telles Mathias, Judymara Lauzi Gozzani   +3 more
doaj   +1 more source

Effect of behavioral intervention using smartphone application for preoperative anxiety in pediatric patients [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundChildren and parents experience significant anxiety and distress during the preoperative period. This is important because preoperative anxiety in children is associated with adverse postoperative outcome.
Jong-Hyuk Lee, Han-Kil Jung, Gang-geun Lee, Han-Young Kim, Sun-Gyoo Park, Seong-Chang Woo   +5 more
doaj   +1 more source

WSGC@FA@PEG/PEI‐SPIONs Mitigate Chemoresistance in Gastric Adenocarcinoma by Modulating the Notch Signaling Pathway and Mitophagy

Advanced Science, EarlyView.
WSGC peptide reverses drug resistance in GA by modulating the Notch signaling pathway and mitophagy at the molecular level. Abstract This study investigates the molecular mechanisms by which superparamagnetic iron oxide nanoparticles (SPIONs) loaded with the WSGC peptide (WSGC@FA@PEG/PEI‐SPIONs)—a 40‐amino acid polypeptide derived from apoC‐III ...
Dongjian Song, Qiuliang Liu, Zechen Yan, Qi Wang, Meng Su, Hui Zhang, Longyan Shi, Yingzhong Fan, Qian Zhang, Heying Yang, Da Zhang   +10 more
wiley   +1 more source

Dynamic stabilization versus fusion for treatment of degenerative spine conditions. [PDF]

, 2011
Study design Comparative effectiveness review.Study rationale Spinal fusion is believed to accelerate the degeneration of the vertebral segment above or below the fusion site, a condition called adjacent segment disease (ASD).
Chou, Dean, Ecker, Erika, Lau, Darryl, Skelly, Andrea   +3 more
core   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Outcomes following oesophagectomy in patients with oesophageal cancer: a secondary analysis of the ICNARC Case Mix Programme Database [PDF]

, 2009
Introduction: This report describes the case mix and outcomes of patients with oesophageal cancer admitted to adult critical care units following elective oesophageal surgery in England, Wales and Northern Ireland.
Alderson, Derek, Cromwell, David A., Harrison, D. A. (David A.), Palser, Thomas R., Park, Daniel P., Perkins, Gavin D., Rowan, Katherine M., Smith, F. Gao (Fang Gao), Welch, Catherine A.   +8 more
core   +4 more sources

Utilizing Machine Learning Methods for Preoperative Prediction of Postsurgical Mortality and Intensive Care Unit Admission

Annals of Surgery, 2019
Supplemental Digital Content is available in the text Objective: To compare the performance of machine learning models against the traditionally derived Combined Assessment of Risk Encountered in Surgery (CARES) model and the American Society of ...
Calvin Chiew, Nan Liu, T. Wong, Y. E. Sim, H. Abdullah   +4 more
semanticscholar   +1 more source

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source