Results 81 to 90 of about 5,183,027 (367)

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Engineering Bacterial Secretion Systems for Enhanced Tumor Imaging and Surgical Guidance

Advanced Materials, EarlyView.
This study presents a novel contrast agent platform, Streptavidin Associated Salmonella (SAS), for fluorescence image guided surgery. SAS selectively colonizes tumors and secretes streptavidin, enabling precise delineation of invasive tumor margins with prolonged signal retention.
Dohee Lee, Heung Jin Jeon, Dohyub Jang, Deukhee Lee, Solbi Kim, Minju Han, Sharon Jiyoon Jung, Jung‐Hyun Lee, Jia Choi, Dong Ha Kim, Dong June Ahn, Keri Kim, Sehoon Kim, Hyo‐Jin Lee, SeungBeum Suh   +14 more
wiley   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Evaluating the efficacy of a smartphone application in reducing preoperative anxiety in children: A randomised controlled trial

Indian Journal of Anaesthesia
Background and Aims: Preoperative anxiety is a common issue in paediatric patients, which can negatively impact perioperative outcomes. While various interventions have been explored, the use of smartphone applications (apps) remains underinvestigated ...
Yiting Pan, Lichun Wan, Qineng Xue, Guo Ran, Kaizheng Chen, Xia Shen   +5 more
doaj   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Effects of Pre-emptive Aortic Side Branch Embolization on Early-Stage Type II Endoleaks and Sac Changes After Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm

Vascular Specialist International
Purpose: This study evaluated the effect of pre-emptive embolization of the aortic side branches on the short-term incidence of type II endoleaks (T2ELs) and aneurysm sac changes following endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms
Hyeonju Kim, Deokbi Hwang, Seung Huh, Woo-Sung Yun, Hyung-Kee Kim   +4 more
doaj   +1 more source

A comparison of the effects of oral vs. intravenous hydration on subclinical acute kidney injury: a protocol of a randomised controlled trial [PDF]

, 2017
Background: Optimal treatment for established renal failure is living donor kidney transplantation. However this pathway exposes healthy individuals to significant reduction in nephron mass via major surgical procedure.
Aitken, Emma, Clancy, Marc, Ghita, Ryan, Mackinnon, Shona   +3 more
core   +1 more source

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source

Costs and Time Loss from Pre-Anesthesia Consultations for Canceled Surgeries: A Retrospective Study at Aachen University Hospital in Germany

Anesthesia Research
Background: In Germany, over 16 million pre-anesthesia consultations (PAC) are conducted annually, which is associated with a significant investment of time and high costs.
Julia Alexandra Simons, Steffen B. Wiegand, Lisa Thiehoff, Patrick Winnersbach, Gereon Schälte, Anna Fischbach   +5 more
doaj   +1 more source

Utilizing Machine Learning Methods for Preoperative Prediction of Postsurgical Mortality and Intensive Care Unit Admission

Annals of Surgery, 2019
Supplemental Digital Content is available in the text Objective: To compare the performance of machine learning models against the traditionally derived Combined Assessment of Risk Encountered in Surgery (CARES) model and the American Society of ...
Calvin Chiew, Nan Liu, T. Wong, Y. E. Sim, H. Abdullah   +4 more
semanticscholar   +1 more source