Results 91 to 100 of about 5,384,967 (304)

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

Design of a nursing psychoeducation program to reduce preoperative anxiety in adults

Frontiers in Public Health
IntroductionPreoperative anxiety, with its multifactorial origins, affects a wide range of surgical patients, leading to adverse physiological and psychological effects in the perioperative period.
Palmira Oliveira, Palmira Oliveira, Regina Pires, Regina Pires, Rosa Silva, Rosa Silva, Carlos Sequeira, Carlos Sequeira   +7 more
doaj   +1 more source

Evaluating the Correlation Between Preoperative Examination Results, Prognosis, and Pathology Results in Temporal Lobe Epilepsy Patients

, 2020
Objectives:This prospective study aims to compare the diagnostic value of different preoperative examinations in patients who underwent TLE surgery for treatment-resistant temporal lobe epilepsy, following histopathological evaluations, and to evaluate ...
Özgür AKDEMİR, Erhan BİLİR, Akdemir, Ozgur, Ali Yusuf ONER, YILDIRIM, İREM, İrem YILDIRIM, KURT, GÖKHAN, Bilir, Erhan, Meltem KARACAN GÖLEN, Gökhan KURT, ÖNER, ALİ YUSUF, Karacan Golen, Meltem   +11 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Preoperative Warming Versus no Preoperative Warming for Maintenance of Normothermia in Women Receiving Intrathecal Morphine for Cesarean Delivery: A Single-Blinded, Randomized Controlled Trial [PDF]

, 2018
BACKGROUND: Rates of hypothermia for women undergoing spinal anesthesia for cesarean delivery are high and prevention is desirable. This trial compared the effectiveness of preoperative warming versus usual care among women receiving intrathecal morphine,
Judy Munday, Yates, Patsy, Sonya Osborne, Osborne, Sonya, Patsy Yates, David Sturgess, Munday, Judy, Jones, Lee, Sturgess, David, Gosden, Edward, Lee Jones, Edward Gosden   +11 more
core   +2 more sources

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Implementation of an integrated preoperative care pathway and regional electronic clinical portal for preoperative assessment [PDF]

, 2014
Background: Effective surgical pre-assessment will depend upon the collection of relevant medical information, good data management and communication between the members of the preoperative multi-disciplinary team.
Frances S Mair, Mair, Frances S, Bouamrane, Matt-Mouley, Mair, Frances, Matt-Mouley Bouamrane   +4 more
core   +2 more sources

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Ameliyat Öncesi Açlık Hakkında Hemşirelerin Bilgi, Tutum Ve Uygulamalarının Güncel Rehberlere Uygunluğunun Değerlendirilmesi

Güncel Hemşirelik Araştırmaları Dergisi, 2022
Amaç: Bu çalışmada, ameliyat öncesi hastaların oral sıvı/besin alımının kısıtlanması konusunda hemşirelerin bilgi, tutum ve uygulamalarının güncel rehberlere uygunluğu araştırıldı.
Ayla Yava, Elif Akyiğit, Hatice Tetik Metin, Ali Güzel   +3 more
doaj  

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source