Results 251 to 260 of about 9,170,294 (335)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Microalga Chlorella vulgaris Supplements as a Factor Increasing the Survival of Potentially Probiotic Lactic Acid Bacteria Under Environmental Stress Conditions. [PDF]

Environ Microbiol Rep
Adamski P, Kłębukowska L.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Precision in Prosthodontic Preparation: An In Vitro Study on the Digital Evaluation of Total Occlusal Convergence Angles Using Varying Magnification Loupes. [PDF]

Cureus
Moturi S, Patro TK, Dhal A, Garhnayak L, Kumar U.   +4 more
europepmc   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Pre-stenting lesion preparation using shockwave intravascular lithotripsy in severely calcified superior mesenteric artery stenosis. [PDF]

CVIR Endovasc
Terzis R, Reimer RWM, Maintz D, Celik E.
europepmc   +1 more source

A Novel Synthesis of Pyridazinones: Preparation of 3-[1-Aryl-6(1H)-pyridazinon-3-yl]-2(1H)-quinoxalinones

, 1987
Adel Amer, El Sayed H. El Ashry, Yeldez El Kilany   +2 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Artificial intelligence for personalized management of vestibular schwannoma: a multidisciplinary clinical implementation study. [PDF]

JAMIA Open
Wijethilake N, Connor S, Oviedova A, Ivory M, Burger R, De Leon De Sagun J, Hitchings A, Abougamil A, Giannis T, Syrris C, Chia K, Al-Salihi O, Obholzer R, Jiang D, Maratos E, Barazi S, Thomas N, Vercauteren T, Shapey J.   +18 more
europepmc   +1 more source