Results 51 to 60 of about 3,730,080 (218)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Cryopreserved Umbilical Cord Mesenchymal Stem Cells Show Comparable Effects to Un-Cryopreserved Cells in Treating Osteoarthritis

Cell Transplantation
Non-cryo and hypothermic preservations are two available options for short-term storage of living cells. For long-term cell storage, cryopreservation is an essential procedure as it prolongs the storage time, allowing for the transport and testing of ...
Bo Yan, Huixin Chen, Li Yan, Qiang Yuan, Le Guo   +4 more
doaj   +1 more source

Effects of Fluoroquinolone Antibiotics on Denitrification in Groundwater: A Review

Yankuang ceshi
Microbially mediated denitrification is essential for nitrate removal in groundwater. Fluoroquinolones (FQs) pollution, mainly from reclaimed water and livestock farming, often co-occurs with nitrate and may influence denitrification. Recent studies have
Hua ZOU, Jiangtao HE, Fei LIU, Qiwen XIA, Yanjia CHU   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Andrographolide Inhibits the NF-κB Signaling Pathway and Alleviates High-Fat Diet-Induced Hepatic Inflammation in a Mouse Model of Nonalcoholic Fatty Liver Disease

Natural Product Communications
Background High-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) is a key link between several medical conditions and is becoming a major health concern affecting thousands of people globally.
Weiwen Hu, Yilin Chen, Wenhong Tan, Yirong Wang, Die Huang, Hao Yuan   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Novel Photo-Responsive Molecularly Imprinted Silica as a Sustainable Solid-Phase Extraction Filler for Highly Selective Adsorption of Chlorogenic Acid

Separations
Chlorogenic acid (CA) is an important natural antioxidant component and holds strong potential for health food and cosmetic applications. In this study, a silica-based photo-responsive molecular imprinting material (PMI-PDA@NH2-SiO2) was designed as a ...
Ying Yang, Xiaofei Xie, Jingchang Zhang, Jirui Sui, Chuancheng Lin, Mingxing Li, Weixue Liu, Chunying Li, Chunjian Zhao   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Research progress on active peptides in marine fish

Food Science of Animal Products
With the deepening research on marine resources, active peptides from marine fish have gradually become a hot spot. This review based on the background of the important value and broad application prospect of active peptides in marine fish.
Hao Duan, Gaigai Liu, Jiaqi Liu, Xinyue Chang, Shuyuan Bao, Wei Song, Wenjie Yan   +6 more
doaj   +1 more source