Results 71 to 80 of about 8,292 (257)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Assessing Noise Pollution and its Impact on Student’s Blood Pressure and Their Learning Performance in Palestine

MATEC Web of Conferences, 2018
The aim of this research was to assess noise pollution trends and to examine the relationship between noise levels and blood pressure (systolic and diastolic), pulse rate and the students’ performance at several Palestinian preparatory and secondary ...
Hustim Muralia, El Zaza Alaa, Al Madhoun Wesam, Heen Ziad Abu, Aly S Hamid, Ramli Muhammad Isran   +5 more
doaj   +1 more source

Environmental Issues in the Context of Health Support in the Thinking of Student Teachers

Communications, 2007
The author presents the results of research among future teachers of lower classes of elementary schools on environmental issues - specifically on the issue of an environmentally friendly lifestyle in the context of health support.
Hana Horka
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

ELEMENTARY MATHEMATICS EDUCATION OF PRESCHOOL CHILDREN IN THE UKRAINIAN HIGHLANDS

Journal of Vasyl Stefanyk Precarpathian National University, 2015
 The paper highlights the challenges of establishment and characteristics of educational institutions functioning in the highlands. It is analyzed the work of preparatory groups that are meant to replace kindergartens in the remote mountainous areas in ...
Ruslana Romanyshyn
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Déclamations, discussions et procès fictifs: continuité et discontinuité de l’imitatio fori

Annali Online dell'Università di Ferrara. Sezione Lettere, 2015
Quintilian (Inst. or. II, 4, 41) aims to underline the didactic goal of the preparatory exercises in the schools of rhetoric. The imitatio fori has got, during the centuries, many fans and followers, who created, nowadays too, new types and kinds of ...
Luigi Spina
doaj   +1 more source

Risk factors of induced abortion among preparatory school student in Guraghe zone, Southern region, Ethiopia: a cross-sectional study

BMC Women's Health, 2019
Background Induced abortion is a common undergo in many societies of the world. Every year, around 20 million unsafe abortions are done worldwide. From fragmented studies conducted in Ethiopia, the prevalence of induced abortion and its adverse effects ...
Kifle Lentiro, Teklemichael Gebru, Abdusemed Worku, Agizie Asfaw, Tigist Gebremariam, Addisu Tesfaye   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source