Results 61 to 70 of about 245,838 (332)
Australian University Nursing and Allied Health Students’ and Staff Physical Activity Promotion Preparedness and Knowledge: A Pre-Post Study Using an Educational Intervention [PDF]
, 2022 Nicole Freene +13 more
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Aerosol and Air Quality ResearchPurpose Agricultural biomass burning is a major source of seasonal PM2.5 emissions in Southeast Asia. Monitoring this pollution remains challenging due to its large spatial extent and the fragmented, small-scale nature of emission sources.
Beomgeun Jang +3 more
doaj +1 more source
International Journal of Infectious DiseasesBackground: The continuing avian influenza outbreaks in animals pose a public health threat worldwide. Concerns about the risk for humans are raising, now we see spread among different mammal species and animal to human transmission.
Dr Anja Schreijer +6 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Machine learning and artificial intelligence to aid climate change research and preparedness
Environmental Research Letters, 2019 Climate change challenges societal functioning, likely requiring considerable adaptation to cope with future altered weather patterns. Machine learning (ML) algorithms have advanced dramatically, triggering breakthroughs in other research sectors, and ...
C. Huntingford +5 more
semanticscholar +1 more source
Factors affecting household disaster preparedness in South Korea
PLoS ONE, 2022 This study examines current household disaster preparedness and identifies its predictors in South Korea. A structured online survey was administered to 1,243 participants quota-sampled by age and population from each administrative district.
Yujeong Kim, M. Y. Kim
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Dynamics in protein translation sustaining T cell preparedness
Nature Immunology, 2020 In response to pathogenic threats, naive T cells rapidly transition from a quiescent to an activated state, yet the underlying mechanisms are incompletely understood.
Tobias Wolf +18 more
semanticscholar +1 more source