Results 31 to 40 of about 7,873 (193)

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Solitary angiokeratoma presenting as cutaneous horn over the prepuce: A rare appearance

Indian Journal of Dermatology, 2016
We present a case of a 47-year-old man with 4 months history of conical growth on the prepuce with a progressive increase in size. The patient had been treated for seminoma a decade ago. Histopathology of the growth showed features of angiokeratoma.
Manoj Kumar Agarwala, Sramana Mukhopadhyay, M Raja Sekhar, Aswathy Menon, C V Dincy Peter   +4 more
doaj   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, EarlyView.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Electrodeposited Functional Coatings for On‐Demand Electro‐Responsive Drug Release and Cell Shape Transformation

Macromolecular Materials and Engineering, EarlyView.
Graphical abstract showing the biocompatible conductive polymer film which releases the entrapped drug as a response to a stimulus (applied voltage) along with mitigating bacterial growth. ABSTRACT Chronic wounds affect millions of people worldwide, and their treatment can often be ineffective, resulting in substantial healthcare costs.
Sanjana Auditto, Riccardo Carzino, Maria Summa, Michele Oneto, Marco Scotto, Niloofar Paknezhad, Simone Lauciello, Paolo Bianchini, Rosalia Bertorelli, Athanassia Athanassiou   +9 more
wiley   +1 more source

Advances in the study of the correlation between balanoposthitis and skin microecology

Frontiers in Microbiology
Balanoposthitis is a common heterogeneous skin condition involving the glans penis and prepuce, and is seen from infancy to old age. Its predisposing factors are intertrigo, lengthy foreskin, localized irritation, and mucosal injury. The itching and skin
Mingyue Wang, Mingyue Wang, Xinghua Gao, Xinghua Gao, Li Zhang, Li Zhang   +5 more
doaj   +1 more source

Age-specific Prevalence Rates of Phimosis and Circumcision in Taiwanese Boys

Journal of the Formosan Medical Association, 2007
To estimate the age-specific prevalence rates of phimosis and circumcision in an urban sample of Taiwanese boys. Methods: A convenience sample of 1145 boys aged from 7 to 13 years was enrolled and cross-sectionally evaluated for preputial retractability ...
Ming-Chung Ko, Chih-Kuang Liu, Wen-Kai Lee, Huey-Sheng Jeng, Han-Sun Chiang, Chung-Yi Li   +5 more
doaj   +1 more source

First Vasectomy Procedure Successfully Performed on a Southern African Male Giraffe (Giraffa camelopardalis giraffa)

Zoo Biology, EarlyView.
First successful vasectomy in a southern African male giraffe, Giraffa camelopardis giraffa ABSTRACT This study reports the first successful vasectomy on a southern African male giraffe (Giraffa camelopardalis giraffa). The goal of the procedure was to create a teaser male for reproductive studies.
Francois Deacon, Willem Daffue, Edward Collin Albertyn, Susanna Maria Krüger, Ayanda Maqhashu, Jacquiline Goedhals, Andri Grobbelaar, Marike Badenhorst   +7 more
wiley   +1 more source

A Comparative Study on Density of Nerve Fibers of Calcitonin Gene-Related Peptide, Protein Gene Product 9.5, and Substance P in Inner and Outer Layers of Prepuce of Male Genitalia

مجله دانشکده پزشکی اصفهان, 2012
Background: Circumcision of boys has been the tradition of all the prophets and has also been emphasized in Islam. Despite the religious teachings, reference books do not provide a standard on how much of the prepuce to leave.
Ardeshir Talebi, Mehrdad Memarzadeh, Nasrin Rasihdi   +2 more
doaj