Results 311 to 320 of about 4,371,529 (377)

Understanding factors that influence the drug choice of prescribers: A Q‐methodology study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Therapeutic decision‐making often involves weighing several treatment options on the basis of, among other things, the disease profile, patient characteristics but also prescriber‐specific factors. This study investigated the factors influencing therapeutic decision‐making among prescribers and explores how these factors differ ...
Mariëlle G. Hartjes   +5 more
wiley   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang   +7 more
wiley   +1 more source

Antiepileptic drug utilization: a Danish prescription database analysis

open access: gold, 2001
Per Rochat   +3 more
openalex   +1 more source

Education about deprescribing for pre‐licensed and licensed healthcare professionals: A scoping review

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Deprescribing is complex because it involves patients' health, values, and preferences. The World Health Organization and Canadian Medication Appropriateness and Deprescribing Network have recommended that deprescribing be integrated into health curricula, prompting the need for further understanding about deprescribing education.
Brian J. Chow   +3 more
wiley   +1 more source

General practitioner consultation for postmenopausal bleeding after COVID‐19 vaccination—a self‐controlled cohort study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims The incidence of postmenopausal bleeding (PMB) has been increasing over the past years. Little is known about the risk of PMB after COVID‐19 vaccination. Our study aimed to investigate this based on routine general practitioner (GP) healthcare data from the Netherlands.
Rana Jajou   +5 more
wiley   +1 more source

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra   +4 more
wiley   +1 more source

Implementation of mass pharmacogenetic testing: Dihydropyrimidine dehydrogenase testing prior to fluoropyrimidine treatment for patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Pharmacogenomics enables personalization of drug therapy improving effectiveness and/or safety. Dihydropyrimidine dehydrogenase [DPYD] testing prior to fluoropyrimidine chemotherapy was commissioned by NHS England in response to an update from the Medicines and Healthcare products Regulatory Agency.
Nisha Shaunak   +5 more
wiley   +1 more source

Best fit framework synthesis of qualitative studies on factors associated with medication nonadherence in people with type 2 diabetes using the COM‐B model

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
This review aimed to synthesize factors associated with medication nonadherence among people with type 2 diabetes (PwT2D), using the Capability, Opportunity, Motivation and Behaviour (COM‐B) model as the a priori model. Studies published between January 2014 and April 2024 were searched on five databases.
Vivien Teo, John Weinman, Kai Zhen Yap
wiley   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård   +7 more
wiley   +1 more source

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