Results 231 to 240 of about 2,687,647 (288)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Opening Pandora's box in the emergency room: a secondary analysis of existential needs from observational, registered nurse, and patient perspectives. [PDF]

BMC Nurs
Pavedahl V, Meranius MS, Muntlin Å.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The effects of cognitive emotion regulation on academic buoyancy among undergraduate students: the mediating role of meaning in life and the moderating role of gender. [PDF]

BMC Psychol
Asghari M, Mohsenpour M, Abdollahi A.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Phenomenon-oriented lifeworld-led data generation in qualitative research-challenging absent or inadequate choices of methods. [PDF]

Int J Qual Stud Health Well-being
Dahlberg H, Holmberg C, Dahlberg K, Pértega E.   +3 more
europepmc   +1 more source

Meaning in life improves response to others' self-promotion. [PDF]

Sci Rep
Huh YE, Scopelliti I, Myaeng SY.
europepmc   +1 more source

Are you weary of illness? Coping and existential positioning in life with myasthenia gravis. [PDF]

Med Health Care Philos
Missel M, Witting N, Beck M.
europepmc   +1 more source

Self-esteem and existential distress among patients with advanced cancer: mediation by a sense of control and meaning in life. [PDF]

Front Psychol
Xu G, Chen G, Zou H, Wei Y, Xiao H.
europepmc   +1 more source

A Person-Centred Approach to Organ Donation Decision-Making After Brain Death: A Case Report. [PDF]

Cureus
Kitsiou M, Tsiokanou P.
europepmc   +1 more source