Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Tribute to John O’Brien (1946 - 2025)
Journal of Awareness-Based Systems ChangeThis collective tribute honors the life and work of John O’Brien (1946–2025), a philosopher, social innovator, and founding figure in person-centered planning and inclusion movements worldwide.
David Hasbury +5 more
doaj +1 more source
Triple-loop learning as foundation for profound change, individual cultivation, and radical innovation: Construction processes beyond scientific and rational knowledge. [PDF]
Purpose: How does new knowledge or profound change come about and which processes of construction are involved? This article aims at developing an epistemological as well as methodological framework which is capable of explaining how profound and radical
Peschl, Markus F.
core +1 more source
Cardioversion from Atrial Fibrillation without Prolonged Anticoagulation with Use of Transesophageal Echocardiography to Exclude the Presence of Atrial Thrombi [PDF]
, 1993 Warren J. Manning +4 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Editors’ Introduction: Imaginary Futures
LateralThis issue introduction reflects on the upcoming 2025 Cultural Studies Association Annual Conference theme, “Imaginary Futures,” and cultural studies futures. This issue contains several articles that address the “presencing” of possible futures, whether
Robert F. Carley +5 more
doaj +1 more source
How does Gross National Happiness offer an integrated perspective linked with health, economics, and nature? [PDF]
J Ayurveda Integr Med, 2023 Richardson JA.
europepmc +1 more source
The Absent Presence of the State in Large-Scale Resource Extraction Projects
, 2021 Bainton, Nicholas A. +1 more
openalex +1 more source