Results 141 to 150 of about 321,867 (325)

Effect of Functionally Graded Material of Disc Spacer with Presence of Multi-Contaminating Particles on Electric Field inside Gas Insulated Bus Duct

, 2013
Mousa Awad Allah Abd Allah, Sayed Abo El Saood Ward, Amr A. Youssef   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nurturing Transformative Capacities

Journal of Awareness-Based Systems Change
Climate science points to the need for rapid and substantial social change. Such a fundamental social transformation requires new methods, paradigms and practices that address not only structural, technological, and systems change, but attend to the ...
Adriene Jenik
doaj   +1 more source

Everyday presences

Cultural Studies, 2004
Andrew Metcalfe, Ann Game
openaire   +1 more source

Severe pelvic pain is associated with sexual abuse experienced during childhood and/or adolescence irrespective of the presence of endometriosis [PDF]

, 2023
Mathilde Bourdon, V. Antoine, U Combes, Lorraine Maitrot‐Mantelet, Louis Marcellin, Chloé Maignien, Charles Chapron, Piétro Santulli   +7 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Te Ruru

Journal of Awareness-Based Systems Change
Indigenous cultures have long-held perspectives that emphasise the interdependence of all living things as holistic systems. Our worldview is thus shaped by deeply embedded relationality, which is in constant response to our interconnected experiences ...
Tom Johnson, Tanya Allport, Amohia Boulton   +2 more
doaj   +1 more source

Heidegger, Will to Power and Gestell [PDF]

For Heidegger Nietzsche is the last metaphysician because he determines truth in relation to the establishment of value-scheme. Heidegger argues that beginning from schematism and its overcoming is starting too late.
Soffer, Joshua
core  

Mechanistic Study of Electrochemical Oxidation of 2,5-Dihydroxybenzoic Acid and 3,4-Dihydroxybenzaldehyde in the Presence of 3-Hydroxy-1H-phenalene-1-one

, 2008
Davood Nematollahi, Ameneh Amani
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source