Results 191 to 200 of about 461,996 (265)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Retrospective Review of Wild and Zoo-Housed Platypus Medical Records (1991-2024). [PDF]

Animals (Basel)
Whinfield J, Vaughan-Higgins R, Vogelnest L, Warren K, Sangster C.   +4 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Towards a more inclusive psychiatry: diversity among presenters and participants in the 25th World Congress of Psychiatry. [PDF]

World Psychiatry
Pinto da Costa M, Dragasek J, Iosue M, Kasparek T, Mohr P, Nyametie M, Wiffen H, Wasserman D.   +7 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Cost of acute hospital treatment and initial aftercare for hospital-presenting self-harm in Ireland: national registry study. [PDF]

BJPsych Open
Cully G, McElroy B, Corcoran P, Puertolas-Gracia B, Kelleher E, Cassidy E, Griffin E.   +6 more
europepmc   +1 more source

Acute Suspected Stroke Clinical Pathway Use in Tasmanian Emergency Departments: A Retrospective Study. [PDF]

Emerg Med Australas
Mudzingwa IT, Prior SJ, Griffin P, Tavender E, Tran V.   +4 more
europepmc   +1 more source

Optimising Retraining Frequency for a Paediatric Emergency Department Admission Prediction Model: Development and Temporal Validation Using Real-World Data. [PDF]

Emerg Med Australas
Williams E, Sinha T, Lyttle M, Kanagasingam Y.   +3 more
europepmc   +1 more source