Results 91 to 100 of about 222,279 (290)

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao, Yikun Yao, Weilong Li, Zigan Xu, Wenjun Hu, Kewang Luo, Peishan Chen, Wanjing Shang, Shaodong Luan, Guojun Shi, Mengtao Cao, Pengfei Chen   +11 more
wiley   +1 more source

Coronary angiography of the ex‐situ beating donor heart in a portable organ care system

Catheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1252-1260, December 1, 2022., 2022
Abstract Objectives To determine safety and feasibility of ex‐situ coronary angiography. Background To cater for the perpetually growing demand for heart donors, interest in donation following circulatory death (DCD) has been rekindled. Further pursuit of donor pool expansion has led to eligibility extension to “marginal” donors who are at higher risk ...
Thomas Meredith, Sarah Scheuer, Michael Hoffman, Yashutosh Joshi, Krishna Kathir, Brendan Gunalingam, David Roy, Stephanie Wilson, Paul Jansz, Peter Macdonald, David Muller   +10 more
wiley   +1 more source

Carotid Artery Vascular Mechanics Serve as Biomarkers of Cognitive Dysfunction in Aortic‐Banded Miniature Swine That Can Be Treated With an Exercise Intervention

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCognitive impairment in the setting of heart failure with preserved ejection fraction remains poorly understood. Using aortic‐banded miniature swine displaying pathological features of human heart failure with preserved ejection fraction, we ...
T. Dylan Olver, Diana Klakotskaia, Brian S. Ferguson, Jessica A. Hiemstra, Todd R. Schachtman, M. Harold Laughlin, Craig A. Emter   +6 more
doaj   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Constraints on mass ejection in black hole formation, derived from black hole X-ray binaries [PDF]

arXiv, 1999
Both the recently observed high runaway velocities of Cyg X-1 (~50 km/s) and X-ray Nova Sco 1994 (> ~100 km/s) and the relatively low radial velocities of the black hole X-ray binaries with low mass donor stars, can be explained by symmetric mass ejection in the supernovae (SNe) which formed the black holes in these systems.
arxiv  

Silent Cerebral Infarctions with Reduced, Mid-Range and Preserved Ejection Fraction in Patients with Heart Failure

Arquivos Brasileiros de Cardiologia
Heart failure predisposes to an increased risk of silent cerebral infarction, and data related to left ventricular ejection fraction are still limited.
Márcia Maria Carneiro Oliveira, Elieusa e Silva Sampaio, Jun Ramos Kawaoka, Maria Amélia Bulhões Hatem, Edmundo José Nassri Câmara, André Maurício Souza Fernandes, Jamary Oliveira-Filho, Roque Aras   +7 more
doaj   +1 more source

Mechanisms of heart failure with well preserved ejection fraction in dogs following limited coronary microembolization [PDF]

, 2004
Kunlun He
openalex   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Heart failure with preserved ejection fraction. Diastolic dysfunction, subtle systolic dysfunction, systolic-ventricular and arterial stiffening, or misdiagnosis? [PDF]

, 2004
Paul Steendijk
openalex   +1 more source

Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine

Advanced Science, EarlyView.
A novel self‐assembled nanomedicine (PMDDH) has been developed for the co‐delivery of doxorubicin and metformin, aiming to enhance the anti‐tumor efficacy of doxorubicin while alleviating its cardiotoxicity through the activation of cGAS‐STING and AMPK signaling pathways, respectively.
Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen   +9 more
wiley   +1 more source