Results 81 to 90 of about 13,112 (262)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Spectral order on unbounded operators and their symmetries

Учёные записки Казанского университета: Серия Физико-математические науки, 2018
The spectral order on positive unbounded operators affiliated with von Neumann algebras have been considered. The spectral order has physical meaning of comparing distribution functions of quantum observables and organizes the structure of unbounded ...
J. Hamhalter, E.A. Turilova
doaj  

Preservers for the Tsallis Entropy of Convex Combinations of Density Operators

Advances in Mathematical Physics, 2018
Let H be a complex separable Hilbert space; we first characterize the unitary equivalence of two density operators by use of Tsallis entropy and then obtain the form of a surjective map on density operators preserving Tsallis entropy of convex ...
Xiaochun Fang, Yihui Lao
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Note on -Potence Preservers on Matrix Spaces over Complex Field

Abstract and Applied Analysis, 2013
Let be the field of all complex numbers, the space of all matrices over , and the subspace of consisting of all symmetric matrices. The map satisfies that is -potent in implying that is -potent in , where then there exist an invertible matrix ...
Xiaofei Song, Chongguang Cao, Baodong Zheng   +2 more
doaj   +1 more source

Medieval Islamic scholarship and writings on sleep and dreams

Annals of Thoracic Medicine, 2018
Islamic civilization between the 7th and the 15th centuries made great contributions to the development of science and medicine, and discoveries made during this time formed the basis for the emergence of the European Renaissance.
Ahmed S BaHammam, Aljohara S Almeneessier, Seithikurippu R Pandi-Perumal   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Kidney Preservation

, 2019
Successful preservation of kidney allografts must counteract the cellular damage evolving after brain death or circulatory arrest. Static cold storage is the simplest method and has therefore been the most widely used. Several preservation fluids have been specially designed for this purpose, but a number of other fluids have been co-opted from other ...
O’Callaghan, John, Oniscu, Gabriel, Leuvenink, Henri, Friend, Peter J., Ploeg, Rutger J.   +4 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source