Results 51 to 60 of about 2,833,793 (296)
Advanced Science, EarlyView.Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin +6 more
wiley +1 more source
Strategic Directions for Gettysburg College Update, February 2011
, 2011 Much has changed since the Strategic Directions for Gettysburg were articulated in 2007. We have had transition in the leadership of the College in key positions including the president, the provost, and the vice president for development, alumni and ...
President\u27s Office,
core
Advanced Science, EarlyView.Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li +16 more
wiley +1 more source
Advanced Science, EarlyView.FM‐DEL1 and FM‐DEL2 are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM‐DELs are screened against markers of prostate, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells.
Francesca Migliorini +12 more
wiley +1 more source
Cât durează starea de urgență? [PDF]
Forum Juridic, 2020 In this article, I shall present the procedure for issuing a presidential decree to institute the state of emergency in accordance with art. 93 of the Constitution, as well as with Emergency Ordinance no.
Bogdan Dima
doaj
Advanced Science, EarlyView.PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao +6 more
wiley +1 more source
King and Cochrane: The technological treadmill and racial inequity in US agriculture
Applied Economic Perspectives and Policy, EarlyView.Abstract Between 1920 and 1969, the number of Black farmers in the US decreased from 14% of all operators to 4%. Using Martin Luther King Jr.'s critique of agricultural policy and Willard Cochrane's theory of the technological treadmill, we explore how racial discrimination was linked to policies that led to structural change in US agriculture.
Jared Hutchins, Jacopo De Marinis
wiley +1 more source
Strategic Directions for Gettysburg College, June 2007
, 2007 Gettysburg is a college deeply rooted in the American experience. It was born of democratic values, strong optimism, and the firm conviction that only a liberal arts education fully awakens and prepares people to live purposeful lives as citizen leaders.
President\u27s Office,
core
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Amidst dwindling state funding and the legislative withdrawal from public university research support, a heightened political process shapes the allocation of scarce tax dollars. This article explores how advocacy within the political process influences funding support for higher education from state legislatures.
Gregory M. Perry +2 more
wiley +1 more source