Results 241 to 250 of about 15,901,010 (309)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Correction: Prevalence and risk factors for stem subsidence following reverse shoulder arthroplasty using on-lay press-fit short stems. [PDF]

Arch Orthop Trauma Surg
Nishiura R, Nakazawa K, Manaka T, Hirakawa Y, Ito Y, Terai H.   +5 more
europepmc   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Full Issue 3(1)

Qualitative Research in Education, 2014
QRE Editor
doaj   +2 more sources

Validation of a digital tool for Moyers mixed dentition analysis: agreement and efficiency compared with the manual method. [PDF]

Dental Press J Orthod
Rodrigues MVB, Squeff LR, Castro ACR, Ruellas ACO, Mota-Júnior SL.   +4 more
europepmc   +1 more source

Standardisation of the Press Coverage System in the Press LaStandardisation of the Press Coverage System in the Press Laww

Journal of Law, Policy and Globalization, 2019
openaire   +2 more sources

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Brain-Wide Activations Related to Forepaw Force Control Identified by Behaving Mouse FMRI. [PDF]

eNeuro
Jindal V, Veizaj J, Schuler Z, de Jesus E, Wesson DW, Vaillancourt D, Vahdat S.   +6 more
europepmc   +1 more source

Dissociable roles of prefrontal plasticity in decision-making strategy and execution of habitual behavior. [PDF]

Nat Commun
Asaoka N, Pagano D, Hayashi Y.
europepmc   +1 more source

Cumulative revision rates in total hip arthroplasty depending on acetabular cup fixation: an analysis from the German arthroplasty registry. [PDF]

Arthroplasty
Zellner AA, Grimberg A, Wu Y, Babasiz M, Fröschen FS, Wirtz DC.   +5 more
europepmc   +1 more source