Results 51 to 60 of about 1,990,907 (242)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Coverage of VOX in Spanish media: Spain’s far-right between mainstreaming and pariahing
Estudios sobre el Mensaje Periodísticola ausencia de un partido populista de derecha radical, pero la irrupción de VOX ha significado la aparición de un contendiente de extrema derecha con éxito electoral.
Gustavo Miguel Rodríguez Hidalgo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
What is non-formal learning (and how do we know it when we see it)? A pilot study report
Discover EducationIn this paper we consider the issue of formality in learning. Both formal and informal learning appear to be well-defined in educational discourse, in contrast with non-formal learning which is less clearly articulated.
Martin Johnson, Dominika Majewska
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
“Press, press, press, press, press” Gender and Afro-Latina identity in Cardi B’s music videos
Überschneidungen von geschlechtlicher, sexueller und ethnischer Identität sind von besonderer Bedeutung in den Musikvideos von Cardi B. In dieser Arbeit werden „Press“ und „Be Careful“, d. h. sowohl die Musik als auch die dazugehörigen Videos, als zwei eigenständige Werke analysiert, die jeweils unterschiedliche Aspekte dieser Intersektion behandeln ...
Fühler, Adrian, Gruner, Juliette
openaire +3 more sources