Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Bulk Nanocrystalline Thermoelectrics Based on Bi-Sb-Te Solid Solution [PDF]
A nanopowder from p-Bi-Sb-Te with particles ~ 10 nm were fabricated by the ball milling using different technological modes. Cold and hot pressing at different conditions and also SPS process were used for consolidation of the powder into a bulk ...
Blank, V. D. +10 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Role for the prefrontal cortex in supporting singular demonstrative reference [PDF]
One of the most pressing questions concerning singular demonstrative mental contents is what makes their content singular: that is to say, what makes it the case that individual objects are the representata of these mental states.
de Carvalho, Felipe Nogueira +1 more
core +1 more source
Mechanical properties and thermal behaviour of two-stage concrete containing palm oil fuel ash [PDF]
Two-stage concrete (TSC) is a special type of concrete which is made by placing coarse aggregate in a formwork and injecting a grout either by pump or under the gravity force to fill the voids. Over the decades, the application of supplementary cementing
Abdul Awal, A.S.M. +3 more
core +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
The role of polymerization cycle and post-pressing time on tooth movement in complete dentures
This study analyzed the influence of polymerization cycle and post-pressing time on tooth movement in complete dentures. Forty maxillary complete dentures were fabricated and randomly assigned to 8 groups (n = 5); the polymerization cycle (conventional ...
Wagner Araujo de Negreiros +4 more
doaj +1 more source
What are the Relationships Between Job and Organizational Tenure, and Job Performance? [PDF]
A pressing issue for companies with a strong focus on internal development is maximizing employee performance within a given role before the employee moves into a new position. Further, companies may seek to understand when the performance impact of firm-
Bartlomiejczuk, Greg
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
KARAKTERISTIK PAPAN PARTIKEL DARI BAMBU DENGAN PEREKAT GETAH DAMAR
The fiber content of bamboo is very high (59.8%), thus it is potential to be the raw material for particle board manufacture. In this study, resin of damar was used as adhesive to substitute the synthetic adhesive such as urea and phenol formaldehide ...
Ika Amalia Kartika, Dara Fegy Pratiwi
doaj +1 more source

