Results 171 to 180 of about 13,218,212 (303)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Isometric exercise training and blood pressure control: exploring the dose-response to training frequency in a randomised controlled trial. [PDF]

BMJ Open Sport Exerc Med
Swift HT, Pedlar C, Coleman DA, Buckley JP, Wiles JD.   +4 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Guidelines in Action: Cognitive Outcomes and Blood Pressure Control. [PDF]

Stroke
Sheibani N, Yadollahikhales G, Simpkins AN.   +2 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Trends in Blood Pressure Control During the COVID-19 Pandemic: A Study of 17 US Health Systems in the National Patient-Centered Clinical Research Network Blood Pressure Control Laboratory. [PDF]

J Am Heart Assoc
Chamberlain AM, Cooper-DeHoff RM, Fontil V, Park S, Shaw KM, Smith M, Carton T, O'Brien EC, Faulkner Modrow M, Wozniak G, Rakotz M, Smith SM, Kappelman MD, Ford DE, Williams DA, Reynolds Geary C, Litvin C, VanWormer JJ, Mosa ASM, Cowell LG, Taylor BW, Chrischilles EA, Pletcher MJ.   +22 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Blood Pressure Control in Adolescents With CKD and Risk of Kidney Failure in Young Adulthood. [PDF]

Kidney Med
Glenn DA, Botdorf M, Allen A, Dickinson K, Wieand K, Davies AG, Besser V, Dixon BP, Gluck C, Hammond J, Harshman L, Kallash M, Katsoufis C, Kibrom S, Kula A, Mitsnefes M, Miyashita Y, Modi Z, Patterson L, Denburg MR, Forrest CB, Zee J.   +21 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Factors associated with non-adherence to antihypertensive therapy and blood pressure control in Iraq. [PDF]

Front Pharmacol
AbdElrahman M, Al-Oudahl GA, Owadh HK, Saleh A, Hassan GK, Mohsen SA, Haider UA, Abd-Alredah AA, Hussein MA, Abdul-Abbas ML, Mojed AM, Obaid AS, Kassem AB.   +12 more
europepmc   +1 more source