Results 101 to 110 of about 2,248,909 (304)

Constant-pressure sound waves in non-Hermitian disordered media

, 2018
When waves impinge on a disordered material they are back-scattered and form a highly complex interference pattern. Suppressing any such distortions in the free propagation of a wave is a challenging task with many applications in a number of different ...
Brandstötter, Andre, Fleury, Romain, Lissek, Hervé, Makris, Konstantinos G., Rivet, Etienne, Rotter, Stefan   +5 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

CURRENT GAIN IN UNIPOLAR PULSED DISCHARGE IN LOW-PRESSURE CARBON DIOXIDE

East European Journal of Physics, 2017
An unipolar low-pressure pulsed discharge (0.1-0.5 Torr) in CO2 has been investigated in the frequency range 20–200 kHz with duty cycle of 0.1 to 0.85 and voltage amplitude of 600–1000 V. It was found that the current gain phenomenon, observed earlier in
V. A. Lisovskiy, S. V. Dudin, N. N. Vusyk, V. A. Volkov, V. D. Yegorenkov, A. N. Dakhov, P. A. Ogloblina   +6 more
doaj  

The effect of the abdominal perfusion pressure on visceral circulation in critically ill patients with multiorgan dysfunction

Egyptian Journal of Critical Care Medicine, 2015
Ongoing studies investigating the intra abdominal pressure (IAP) shifted the belief of mesenteric circulation not to be only a culprit of decreased arterial hypoperfusion, but also other hydrostatic forces may impose its perfusion and may also act ...
H. ELatroush, N. Abed, A. Metwaly, M. Afify, M. Hussien   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A shut-in pressure calculation method for high-temperature high-pressure wells in deepwater fractured formations based on thermo-hydro-mechanical coupling

Petroleum Exploration and Development
By comprehensively considering the influences of temperature and pressure on fluid density in high temperature and high pressure (HTHP) wells in deepwater fractured formations and the effects of formation fracture deformation on well shut-in afterflow ...
Gang CHEN, Zhiyuan WANG, Xiaohui SUN, Jie ZHONG, Jianbo ZHANG, Xueqi LIU, Mingwei ZHANG, Baojiang SUN   +7 more
doaj   +1 more source

The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study

BMC Anesthesiology, 2011
Background The insertion of Ventricular Assist Devices is a common strategy for cardiovascular support in patients with refractory cardiogenic shock.
Dunster Kimble R, Barnett Adrian G, Ainslie Philip, Tzeng Yu-Chieh, Chan Gregory S, Bellapart Judith, Boots Rob, Fraser John F   +7 more
doaj   +1 more source