Results 111 to 120 of about 4,376,058 (346)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Trajectory Groups of 24‐h Systolic Blood Pressure After Mechanical Thrombectomy and Outcomes
The Journal of Clinical HypertensionElevated blood pressure (BP) following mechanical thrombectomy (MT) has been linked to poorer outcomes, but optimal BP management remains uncertain. This study sought to identify distinct systolic BP (SBP) trajectories in patients after MT and assess ...
Huaishun Wang +5 more
doaj +1 more source
Frontiers in NutritionThis study aims to investigate the influence of psychological ownership of nutritional products on the purchase intention of high-pressure working groups, as well as the underlying mechanisms and boundary conditions of this influence.
Boyu Liang +4 more
doaj +1 more source
Packing topological pressure for amenable group actions [PDF]
Ziqing Ding, Ercai Chen, Xiaoyao Zhou
openalex +3 more sources
Political Pressure on Central Banks: The Case of the Czech National Bank (in English) [PDF]
As the independence of national central banks in the European Union is one of the main institutional features of the EU’s monetary constitution, this paper considers whether central-bank monetary policy is conducted independently or if it is affected by ...
Adam Geršl
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Journal of Marine Science and EngineeringAs the foundation of marine infrastructure, pile groups are subjected to extreme wave loads. Existing research primarily focuses on regular waves and wave forces.
Wanshui Han +4 more
doaj +1 more source