Results 81 to 90 of about 160,144 (264)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A method for measuring surface diffusion coefficient of coal-adsorbed gas using a differential pressure permeation method

Meitan xuebao
The surface diffusion behavior of coal-adsorbed gas is difficult to measure and quantitatively characterize, which has always been a problem or difficulty in the study of the migration law of coalbed methane (coal mine gas).
Shiqiang CHEN, Yugui ZHANG, Mingjie ZHANG, Jiangwei YAN, Cao LIU, Donghui LI, Guangshan SHI   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Laboratory-Scale Miniature Piezocone Framework for Investigating Rate-Dependent Partial Drainage in Intermediate-Permeability Soils

Geotechnics
Penetration rate effects and partial drainage can govern piezocone (CPTu) response in intermediate permeability geomaterials, but field testing at a fixed standard rate limits systematic evaluation.
Henrique Milan, André Luis Meier, Gracieli Dienstmann, Helena Paula Nierwinski, Murilo da Silva Espindola, Orlando Martini Oliveira, Rafael Augusto dos Reis Higashi   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intelligent Modeling of Concrete Permeability Using XGBoost Based on Experimental and Real Data: Evaluation of Pressure, Time, and Severe Conditions

Modelling
Resistance against water penetration is one of the key indicators of concrete durability in humid and pressurized environments. An intelligent model based on the XGBoost machine-learning algorithm was developed to predict the water penetration depth ...
Ali Saberi Varzaneh, Mahmood Naderi
doaj   +1 more source

Pressure equalization and the control of rainwater penetration

, 1992
The rainscreen concept was first referenced as a means of rain penetration control in the 1940's. Later researchers applied physics principles to develop the 'pressure equalized rainscreen principle' as it is known today. Through the development process a selection of terminology has been used to describe the concept which uses a rainscreen to control ...
Poirier, G. F., Brown, W. C., Baskaran, B. A.   +2 more
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Novel Cell Seeding System into a Porous Scaffold Using a Modified Low-Pressure Method to Enhance Cell Seeding Efficiency and Bone Formation

Cell Transplantation, 2007
The efficient seeding of cells into porous scaffolds is important in bone tissue engineering techniques. To enhance efficiency, we modified the previously reported cell seeding techniques using low-pressure conditions.
Ichiro Torigoe, Shinichi Sotome, Akio Tsuchiya, Toshitaka Yoshii, Makoto Takahashi, Shigenori Kawabata, Kenichi Shinomiya   +6 more
doaj   +1 more source