Results 61 to 70 of about 390,980 (293)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Prognostic Value of Absolute versus Relative Rise of Blood Pressure in Pregnancy

, 2002
This study evaluated the prognostic value of absolute versus relative rise in blood pressure during pregnancy at the Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Enugu, Nigeria from 17th December 1997 to 31st March ...
Onah, H.E., H. E. Onah
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Transient flow rate rise (high-speed start).

, 2023
The study on transient characteristics of pump as turbines during atypical startup has not been deeply explored yet. In order to reveal the transient characteristics of a small centrifugal pump reversing as turbine during startup process in this paper ...
You-Qu Zheng (17457941), Yu-Liang Zhang (2441632), Jin-Fu Li (17457938)   +2 more
core   +1 more source

Influence of Ignition Position on Explosion Characteristics in Linked Vessels with a Concentration Gradient

Fire
This study examines the influence of ignition position on explosion characteristics in linked vessels with a methane concentration gradient, aiming to support the safety of industrial combustible gas storage systems.
Xiaoyuan Xu, Kaihua Lu
doaj   +1 more source

A comparative study of efficacy of esmolol and fentanyl for pressure attenuation during laryngoscopy and endotracheal intubation

Saudi Journal of Anaesthesia, 2011
Objective: To compare the effectiveness of single bolus dose of esmolol or fentanyl in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation.
Shobhana Gupta, Purvi Tank
doaj   +1 more source

CFD Modeling of Helium Pressurant Effects on Cryogenic Tank Pressure Rise Rates in Normal Gravity [PDF]

43rd AIAA/ASME/SAE/ASEE Joint Propulsion Conference & Exhibit, 2007
A recently developed computational fluid dynamics modeling capability for cryogenic tanks is used to simulate both self-pressurization from external heating and also depressurization from thermodynamic vent operation. Axisymmetric models using a modified version of the commercially available FLOW-3D software are used to simulate actual physical tests ...
Gary Grayson, Alfredo Lopez, Frank Chandler, Leon Hastings, Ali Hedayat, James Brethour   +5 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Data-driven modeling and predictive control of maximum pressure rise rate in RCCI engines

, 2020
Reactivity controlled compression ignition (RCCI) is a promising low temperature combustion (LTC) regime that offers lower nitrogen oxides (NOx), soot and particulate matter (PM) emissions along with higher combustion efficiency compared to conventional ...
Basina, L. N. Aditya, Jeffrey D. Naber, Shahbakhti, Mahdi, Behrouz K. Irdmousa, Hoseinali Borhan, Irdmousa, B. K., Velni, Javad Mohammadpour, L. N. Aditya Basina, Javad Mohammadpour Velni, Mahdi Shahbakhti, Naber, Jeffrey, Borhan, Hoseinali   +11 more
core   +1 more source