Results 51 to 60 of about 3,139,121 (251)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Patterns of deposition from experimental turbidity currents with reversing buoyancy [PDF]

, 2010
Turbidity currents are turbulent, sediment-laden gravity currents which can be generated in relatively shallow shelf settings and travel downslope before spreading out across deep-water abyssal plains.
Pritchard, David, Gladstone, CHARLOTTE, Gladstone, C.   +2 more
core   +1 more source

Observation of Pressure Stimulated Voltages in rocks using an Electric Potential Sensor

, 2009
Recent interest in the electrical activity in rock and the use of electric field transients as candidates for earthquake precursors has led to studies of pressure stimulated currents in laboratory samples.
H Prance (16059455), C J Harland (16059743), Ahmet Aydin (16058912), Robert Prance (4460476)   +3 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Changes in the physical structure and chain dynamics of elastin network in homocysteine-cultured arteries [PDF]

, 2009
The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries.
Lamy, Edouard, Charpiot, Philippe, Chareyre, Corinne, Lacabanne, Colette, Samouillan, Valérie, Foucault-Bertaud, Alexandrine, Dandurand, Jany   +6 more
core   +1 more source

Electric signal emissions during repeated abrupt uniaxial compressional stress steps in amphibolite from KTB drilling [PDF]

Natural Hazards and Earth System Sciences, 2007
Laboratory experiments have confirmed that the application of uniaxial stress on rock samples is accompanied by the production of weak electric currents, to which the term Pressure Stimulated Currents – PSC has been attributed. In this work the PSC
D. Triantis, C. Anastasiadis, F. Vallianatos, P. Kyriazis, P. Kyriazis, G. Nover   +5 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Experimental analysis of the pressure–velocity correlations of external unsteady flow over rocket launchers [PDF]

, 2013
Based on simultaneous wall pressure and velocity measurements, the aerodynamic load of a launcher body model is investigated. Two different configurations are considered in order to study the influence of geometrical artifacts on the after body flow and ...
DRUAULT, Philippe, MARIÉ, Simon, LAMBARE, Hadrien, SCHRIJER, Ferry, Marie, S., Druault, Ph, Schrijer, F., Lambare, H.   +7 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source