Results 71 to 80 of about 449,166 (315)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

TP2 COPPER TUBE OVERPRESSURE STRENGTHEN TECHNOLOGY AT ROOM TEMPERATURE

Jixie qiangdu, 2019
In order to increase the burst pressure of copper pipe,save the copper material under the premise of guaranteeing safety,overpressure enhancement of TP2 copper tube was tested at room temperature,the relationship between the burst pressure of copper tube
YANG Fan, LIU XiaoNing, LIU Bing, CHEN Gang, CHEN Fan, FAN YouXiong, ZHANG HongWei   +6 more
doaj  

Endotracheal Tube Cuff Pressure Monitoring in Children

Общая реаниматология, 2012
Objective: to estimate tracheal morphological changes in children, by using a device for the continuous monitoring and regulation of endotracheal tube cuff pressure. Subjects and methods. Two groups of children were examined.
V. V. Lazarev, E. M. Kopteva, L. E. Tsypin, I. G. Khamin, D. V. Dorokhov   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Research on flow field characteristic of close-coupled gas atomizing nozzles

Fenmo yejin jishu
The atomization nozzle is the core component for the metal powder preparation by close-coupled gas atomization method. The pressure at the tip of the melt delivery tube and the stagnation point is very important for the smooth outflow of the molten metal
BAN Wei, CHEN Jiaqi, LIU Lulu, GE Tao, ZHANG Shuai   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Experimental Investigation on Evaporation Heat Transfer and Pressure Drop Characteristics of HFC-161 in a Horizontal Smooth Tube

, 2012
The evaporation heat transfer and pressure drop characteristics of HFC-161 in a horizontal smooth tube with an inside diameter of 9 mm was experimentally investigated.
Chen, Guangming, Wang, Xue Hui, Li, Peng, Han, Xiaohong   +3 more
core  

Dynamic and evolution of the CH4 explosion with different vent tube diameters

Case Studies in Thermal Engineering
CH4 explosion in a confined space will cause serious harm, and the vent tube can realize the directional venting of the explosion. Through the explosion experiment and numerical simulation of 8 vol% CH4, the impact of tube diameter on CH4 explosion ...
Wen Zhou, Suyue Li, Shuang Geng, Yue Zhao, Mengyi Yuan, Wenxin An, Wenhao Xing, Xueqiang Shi, Yang Zhang, Weiguo Cao   +9 more
doaj   +1 more source