Results 71 to 80 of about 2,497,341 (230)

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Development and validation of a new patient-reported outcome measure for patients with pressure ulcers: the PU-QOL instrument. [PDF]

, 2013
BACKGROUND: Patient-reported outcome (PRO) data are integral to patient care, policy decision making and healthcare delivery. PRO assessment in pressure ulcers is in its infancy, with few studies including PROs as study outcomes.
Gorecki, C, McGinnis, Elizabeth, Cano, S, Coleman, S, Briggs, Michelle; id_orcid, McGinnis, E, Wilson, L, Briggs, Michelle, Nelson, AE, Nelson, Andrea E, Cano, Stefan, Cano, S. J., Dealey, Carol, Dealey, C, Stubbs, N, Briggs, M, Nixon, J, Lamping, DL, Brown, Julia M., Lamping, D. L., Coleman, Susanne, Nixon, Jane, Lamping, Donna L., Brown, Julia M, Wilson, Lyn, Nelson, Andrea E.; id_orcid, Lamping, Donna L, Stubbs, Nikki, Gorecki, Claudia, Brown, JM   +29 more
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Prevalence of postoperative pressure ulcer: A systematic review and meta-analysis

Electronic Physician, 2016
Introduction: A pressure ulcer is a serious safety issue in healthcare systems. The patient’s rate of infection with an ulcer, especially a postoperative ulcer, is critical, as it is dictated by factors such as being in a fixed position during surgery,
Vida Shafipour, Ensieh Ramezanpour, Mohammad Ali Heidari Gorji, Mahmood Moosazadeh   +3 more
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

The prevalence of pain at pressure areas and pressure ulcers in hospitalised patients. [PDF]

, 2013
Background: Patients with pressure ulcers (PUs) report that pain is their most distressing symptom, but there are few PU pain prevalence studies. We sought to estimate the prevalence of unattributed pressure area related pain (UPAR pain) which was ...
Rivers, Carly, McGinnis, Elizabeth, Coleman, S, Wilson, L, McGinnis, E, Briggs, Michelle, Michelle Collinson, Rivers, C, Nelson, EA, Briggs, M; id_orcid, Susanne Coleman, Collinson, Michelle, Stevenson, Rebecca, Dealey, C, Stubbs, N, Dealey, Carol, Carly Rivers, E Andrea Nelson, Jane Nixon, Michelle Briggs, Briggs, M, Nixon, J, Stevenson, R, Lyn Wilson, Nikki Stubbs, Brown, Julia, Nelson, E Andrea; id_orcid, Collinson, M, Coleman, Susanne, Elizabeth McGinnis, Nixon, Jane, Rebecca Stevenson, Wilson, Lyn, Julia Brown, Stubbs, Nikki, Carol Dealey, Brown, J   +36 more
core   +2 more sources

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

Advanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino, Phuoc Thien Phan, James Davies, Bibhu Sharma, Tianruo Guo, Chi Cong Nguyen, Nigel H. Lovell, Thanh Nho Do   +7 more
wiley   +1 more source

Comparative study on two kinds of pressure ulcer scales on predicting pressure ulcers in patients in operating room

Huli yanjiu, 2019
Objective:To evaluate the predictive ability of various scales on pressure ulcer in surgical patients by the Braden Scale and Risk Factors Assessment Scale for Pressure Ulcer in Surgery Patients developed in the operating room in Second Affiliated ...
陈家琦, 武文静, 张晓红, 薛武鹏   +3 more
doaj  

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source