Results 61 to 70 of about 39,060 (295)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
False Presumptions Counter to the Presumptions of Innocence
Journal of the American Institute of Criminal Law and Criminology, 1917 American criminal procedure is condemned as ineffective, because delay and technicality intervene on behalf of the accused. The sanction of the law is neither swift nor inexorable. Not only do "the wicked flee where no man pursueth," but the prisoner enmeshed is preserved from punishment by over-sedulous respect for his rights. Mr.
openaire +3 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Should We Presume State Protection?
Refuge, 2016 Professors Hathaway and Macklin debate the legality of the “presumption of state protection” that the Supreme Court of Canada established as a matter of Canadian refugee law in the Ward decision.
James C. Hathaway, Audrey Macklin
doaj +1 more source
On the presumption of equality
Critical Review of International Social and Political Philosophy, 2018 According to the presumption of equality, cases should be presumed to be similar when it is not known whether they are similar or different.
openaire +2 more sources
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
IMPACT OF PARENTAL PRESUMPTION ON ADOLESCENTS MENTAL HEALTH AND SUICIDAL THOUGHTS IN TERTIARY INSTITUTIONS IN ANAMBRA STATE-NIGERIA [PDF]
Social Sciences and Education Research ReviewThis study investigated the impact of parental presumption on adolescents' mental health and suicidal thoughts in tertiary institutions in Anambra state-Nigeria.
Nkechi Uzochukwu OKEKE +2 more
doaj +1 more source