Results 61 to 70 of about 452,364 (380)
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Problems of the use of presumption in establishing paternity [PDF]
Introduction. Current Russian legislation regulates the procedure for establishing a legal connection between a born child and his or her father, however, in practice, problems with applying the presumption arise when establishing paternity.
Torosyan, Rima Andranikovna
doaj +1 more source
INTRODUCTION:Substance use disorders (SUD) in physicians often remain concealed for a long time. Peer monitoring and open discussions with colleagues are essential for identifying SUD. However, physicians often feel uncomfortable discussing substance use
Pauline Geuijen +7 more
doaj +1 more source
European court of human rights: case of Axel Springer AG v. Germany [PDF]
Grand Chamber judgment on freedom of expression, privacy and presumption of ...
Voorhoof, Dirk
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Haciendo uso de la teoría semiótica de Greimas, de los principios pragmáticos de cooperatividad y de otras teorías sobre la estructura de la lengua y sobre la argumentación, se sustentan hipótesis relacionadas con algunas estrategias de persuasión ...
Julia Marlén Baquero Velásquez
doaj
Mitochondrial fatty acid oxidation is stimulated by red light irradiation
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera +4 more
wiley +1 more source
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source

