Results 211 to 220 of about 58,866 (354)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Ethical issues in the use of genetic predictions of aggressive behavior in the criminal justice system: a systematic review. [PDF]

Front Genet
Refolo P, Ferracuti S, Grassi S, Raimondi C, Mercuri G, Zedda M, Aulino G, Spagnolo AG, Oliva A.   +8 more
europepmc   +1 more source

Presumptions—The Uniform Rules in the Federal Courts [PDF]

, 1964

core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Constructing criminality: a thematic analysis of national news media reporting on self-managed abortion criminalisation in the United States. [PDF]

Sex Reprod Health Matters
McMahon HV, Pearce N, Smith AJ, Stevenson IC, Howard GE, Redd SK, Rice WS.   +6 more
europepmc   +1 more source

Presumption of Innocence and Confiscation

Journal of Applied Business and Economics, 2020
openaire   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Legal and ethical implications of AI-based crowd analysis: the AI Act and beyond. [PDF]

AI Ethics
Veltmeijer E, Gerritsen C.
europepmc   +1 more source

Presumptions and Assumptions in the Criminal Law: Another View [PDF]

, 1970
Christie, George C., Pye, A. Kenneth
core   +1 more source