Results 51 to 60 of about 7,626 (238)
Enhancing playful interactions: eCoaching mothers of preschool children with disabilities
Journal of Childhood, Education & SocietyPretend play is crucial for developing communication and cognitive skills in preschool children. Targeted coaching during pretend play can effectively support family-centered practices and home-based assistance.
Amanda H. Passmore, Marie Tejero Hughes
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Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
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Formally modeling pretend object play [PDF]
Proceedings of the 8th ACM conference on Creativity and cognition, 2011 We address the problem of building computational agents that are capable of play. Existing research has examined the forms, characteristics, and processes involved in various kinds of play at a high level. However, this research does not provide a unified framework at a level of detail sufficient for building computational agents that can play.
Alexander Zook +2 more
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Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
Education SciencesAs digitalization and digital transformation shape developments in society, children’s competence and agency for digital transformation need to be fostered from an early age. Equitable digital education is of utmost importance.
Lena Hollenstein +3 more
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Pretend play and the cultural foundations of mathematics [PDF]
European Early Childhood Education Research Journal, 2016 The aim of this study is to uncover the emergence of cultural mathematical understandings and communications in young children's spontaneous pretend play. It is based on Vygotskian cultural-historical perspectives and social-semiotic theory, informed by research into ‘funds of knowledge' and considers how children's informal knowledge of family ...
van Oers, B., Worthington, M.
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Advanced Science, EarlyView.Based on orbital magnetic moment control, a material design strategy is proposed for a giant converse magnetoelectric effect in multiferroic heterostructures. This study will pioneer a promising route toward low‐power spintronic devices with an electric field.
Takamasa Usami +5 more
wiley +1 more source
How day-care practitioners support children’s language and play development
International Journal of Educational Research OpenWhile previous research has linked DCP interaction quality to children's language, social, and cognitive outcomes, its connection to play development remains underexplored.
Eline van Rossum +4 more
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Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
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Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source