A plausible role of imagination in pretend play, counterfactual reasoning, and executive functions. [PDF]
Br J Psychol, 2023 Francis GA, Gibson JL.
europepmc +1 more source
Advanced Science, EarlyView.In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu +12 more
wiley +1 more source
"The Red Spots Are Now Lava, We Shouldn't Step on Them"-The Joint Creation of Novel Arbitrary Social Contexts in Pretend Play. [PDF]
Open Mind (Camb), 2023 Andrási K, Király I.
europepmc +1 more source
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Graphene (0002)/Diamond (111) Heterojunction with High Piezoresistive Response
Advanced Science, EarlyView.Graphene/diamond heterostructures show promise as silicon alternatives for semiconductors, but high‐quality integration is challenging. Thermal electron irradiation enables covalent bonding; lonsdaleite acts as an intermediate. The heterostructure exhibits a high piezoresistive response (gauge factor −1149) associated with electron‐rich layers and ...
Xueyu Zhang +10 more
wiley +1 more source
Pretend Play: Young Children’s Acceptance of a Make-Believe Situation
Национальный психологический журналBackground. Despite the development of the concept of play in cultural-historical and activity theory, the issues of playing at an early age remain poorly understood. The present work is aimed at filling this gap. Objectives. To study the acceptance of a
Irina A. Ryabkova +2 more
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Causal learning, counterfactual reasoning and pretend play: a cross-cultural comparison of Peruvian, mixed- and low-socioeconomic status U.S. children. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2022 Wente A +4 more
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Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng +9 more
wiley +1 more source
An exciting Approach to Theoretical Spectroscopy
Advanced Science, EarlyView.ABSTRACT Theoretical spectroscopy, and more generally, electronic‐structure theory, are powerful concepts for describing the complex many‐body interactions in materials. They cover methods from ground‐state properties to lattice excitations and light‐matter interaction, including time‐resolved variants.
Martí Raya‐Moreno +29 more
wiley +1 more source
Pretend Play as a Key to Enhancing Sexuality Knowledge in Children with Mild Intellectual Disability
Ta'dibThis study aims to analyze the effect of the pretend play method on sexuality knowledge in children with mild intellectual disabilities, while controlling for age, concentration, and verbal ability in special needs schools.
Alucyana Alucyana +4 more
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