Results 111 to 120 of about 318,926 (310)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Organs-On-Chip Models of the Female Reproductive System

Bioengineering, 2019
Microfluidic-based technology attracts great interest in cell biology and medicine, in virtue of the ability to better mimic the in vivo cell microenvironment compared to conventional macroscale cell culture platforms.
Vanessa Mancini, Virginia Pensabene
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Helping small babies survive: an evaluation of facility-based Kangaroo Mother Care implementation progress in Uganda

The Pan African Medical Journal, 2014
INTRODUCTION: Prematurity is the leading cause of newborn death in Uganda, accounting for 38% of the nation's 39,000 annual newborn deaths. Kangaroo mother care is a high-impact; cost-effective intervention that has been prioritized in policy in Uganda ...
Patrick Aliganyira, Kate Kerber, Karen Davy, Nathalie Gamache, Namaala Hanifah Sengendo, Anne-Marie Bergh   +5 more
doaj   +1 more source

The immune consequences of preterm birth

Frontiers in Neuroscience, 2013
Preterm birth occurs in 11% of live births globally and accounts for 35% of all newborn deaths. Preterm newborns have immature immune systems, with reduced innate and adaptive immunity; their immune systems may be further compromised by various factors ...
Jacqueline M Melville, Timothy J M Moss, Timothy J M Moss   +2 more
doaj   +1 more source

Inherited predisposition to spontaneous preterm delivery [PDF]

, 2010
Peer ...
Bhattacharya, Sohinee, Norman, Jane E., Campbell, Doris, Lee, Amanda Jane, Lee, Amanda J., Raja, Edwin Amalraj, Norman, Jane, Bhattacharya, Siladitya, Campbell, Doris M., Mirazo, Eider Ruiz, Ruiz-Mirazo, E   +10 more
core   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Association of various postnatal risk factors with progression of retinopathy of prematurity (ROP) in preterm neonates: A case-control study

Journal of Family Medicine and Primary Care
Retinopathy of prematurity (ROP) is a complex disease of the developing retinal vasculature in infants born prematurely and is the leading preventable cause of childhood blindness worldwide. Multiple factors play a significant role in the pathogenesis of
Alisha Gaba, Harijot Singh, Rajwinder Kaur   +2 more
doaj   +1 more source

PRETERM LABOUR:

The Professional Medical Journal, 2017
Objectives: (1) to find out of aetiological factors of preterm labour. (2) To makea proposed remedy for prevention of preterm lobour. Material and Methods: This study wascarried out at Independent University Hospital. This is located at richly populated area ofFaisalabad, providing health care facilities to poor socioeconomic group.
Tasneem Azher, Iram Aslam, Saadia Bano, Uzma Shahzad   +3 more
openaire   +2 more sources

Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth. [PDF]

, 2006
BACKGROUND: We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development.
Ajayi-Obe, M., Nadeem Saeed, Allsop, J. M., Boardman, J., Kennea, N, Morenike Ajayi-Obe, Dyet, L., Jaroslav Stark, Frances Cowan, Saeed Nadeem, Philip Duggan, Allsop Joanna M, Counsell, S. J.; id_orcid, Kennea, N., Ajayi-Obe Morenike, Stark, J., Edwards, AD, Cowan, F, Mary A Rutherford, Joanna M Allsop, Dyet Leigh, Counsell Serena J, Counsell, SJ, Stark, J, Kennea Nigel, Duggan Philip, Maalouf, E, Allsop, JM, Kapellou, O, Jo Hajnal, Leigh Dyet, Rutherford, M. A., Rutherford, MA, Duggan, P., Edwards, A. D.; id_orcid, Ajayi-Obe, M, Maalouf Elia, A David Edwards, Maalouf, E., Boardman James, Cowan, F., Hajnal, J.; id_orcid, Saeed, N, Dyet, L, James Boardman, Cowan Frances, Edwards A. David, Duggan, P, Rutherford Mary A, Hajnal Jo, Elia Maalouf, Olga Kapellou, Kapellou, O., Serena J Counsell, Saeed, N., Hajnal, J, Stark Jaroslav, Boardman, J, Nigel Kennea, Kapellou Olga   +59 more
core   +1 more source