Results 221 to 230 of about 253,680 (299)

Distinct neural mechanisms underlying cognitive difficulties in preterm children born at different stages of prematurity. [PDF]

Neuroimage Clin
Nivins S, Padilla N, Kvanta H, Mårtensson G, Ådén U.   +4 more
europepmc   +1 more source

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

Insights into the alteration of vaginal microbiota and metabolites in pregnant woman with preterm delivery: prospective cohort study. [PDF]

Front Cell Infect Microbiol
Wang L, Zhang J, Zhang M, Xu Z, Zheng Y, Lv B, Pan M.   +6 more
europepmc   +1 more source

From PICU to NICU: Extrapolating Meropenem Exposure From Pediatric to Neonatal Intensive Care Patients

The Journal of Clinical Pharmacology, EarlyView.
Abstract We previously developed a population pharmacokinetic (PopPK) model for meropenem in pediatric intensive care unit patients accounting for effect of body size, maturation, and kidney function on clearance. This study aimed to extrapolate meropenem exposure to neonates and young infants using the pediatric PopPK model and to validate the ...
Ronaldo Morales Junior, Tomoyuki Mizuno, Wen Rui Tan, Kei Irie, Sonya Tang Girdwood   +4 more
wiley   +1 more source

Early-Life Development of the Intestinal Microbiome in Preterm and Term Infants Hospitalized in the Neonatal Intensive Care Unit. [PDF]

Microorganisms
Shin J, Choi CW, Kang HM, Kim SY, Youn YA.   +4 more
europepmc   +1 more source

Assessing cognition in autistic youth with and without attention‐deficit/hyperactivity disorder using the NIH Toolbox Cognition Battery: An Environmental influences on Child Health Outcomes‐Wide Cohort Study

JCPP Advances, EarlyView.
Autistic individuals tend to experience difficulties with fluid cognition as found previously, with minimal impact of ADHD. However, there was a notable proportion of autistic individuals with average or superior cognitive performance, highlighting the importance of strength‐based and transdiagnostic research approaches.
Catrina A. Calub, Aisha S. Dickerson, Haozuo Zhao, Robert M. Joseph, Michael O'Shea, Shaikh I. Ahmad, Lisa A. Croen, Sean C. L. Deoni, Viren A. D’Sa, Akhgar Ghassabian, Daphne Koinis‐Mitchell, Leonardo Trasande, Heather Volk, Anna J. Yeo, Irva Hertz‐Picciotto, Julie B. Schweitzer, Marjorie Solomon, for the ECHO Cohort Consortium   +17 more
wiley   +1 more source

Global, regional, and national time trends in disability-adjusted life years for neonatal preterm birth, from 1992 to 2021: an age-period-cohort analysis for the global burden of disease study 2021. [PDF]

Front Public Health
Wu Y, Zuo J, Liu C, Li Z, Zhang L, Zou Y, Wang X, Chen L, Wang T.   +8 more
europepmc   +1 more source

Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study

JCPP Advances, EarlyView.
Abstract Background Pregnancy complications have been associated with offspring autism spectrum disorders (ASD). There has also been increasing evidence for multigenerational risk factors of ASD. Methods In a multigenerational California birth cohort of 1,740,379 mother–child pairs, we investigated pregnancy complications when the grandmother was ...
Ting Chow, Qi Meng, Jingyuan Xiao, Karl O’Sharkey, Zeyan Liew, Beate Ritz   +5 more
wiley   +1 more source

The impact of changes in health policies caused by COVID-19 on pregnancy outcomes in Iran during health crises: A retrospective quasi-experimental study. [PDF]

BMC Pregnancy Childbirth
Morshed-Behbahani B, Okhovat F, Janghorban R, Bayati M.   +3 more
europepmc   +1 more source

Interhospital variation in the management of Brief Resolved Unexplained Events (BRUE) in infants: A Canadian multicenter cohort study

Journal of Hospital Medicine, EarlyView.
Abstract Background Guidelines on Brief Resolved Unexplained Event (BRUE) only provide recommendations for infants categorized at lower risk. However, most infants fall into the higher‐risk category, leaving management decisions to individual clinicians and contributing to variation in care.
Nassr Nama, Kara Picco, Polina Kyrychenko, Jeffrey N. Bone, Julie Quet, Jessica L. Foulds, Josée Anne Gagnon, Chris Novak, Brigitte Parisien, Matthew Donlan, Ran D. Goldman, Anupam Sehgal, Ronik Kanani, Joanna Holland, Sanjay Mahant, Eric Coon, Joel S. Tieder, Peter J. Gill, The Canadian BRUE Collaboration (C‐BRUE‐C) and the Canadian Paediatric Inpatient Research Network (PIRN)   +18 more
wiley   +1 more source