Results 71 to 80 of about 277,171 (317)

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Organs-On-Chip Models of the Female Reproductive System

Bioengineering, 2019
Microfluidic-based technology attracts great interest in cell biology and medicine, in virtue of the ability to better mimic the in vivo cell microenvironment compared to conventional macroscale cell culture platforms.
Vanessa Mancini, Virginia Pensabene
doaj   +1 more source

GAIA Premature Preterm Rupture of Membranes Levels of Diagnostic Certainty [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Helping small babies survive: an evaluation of facility-based Kangaroo Mother Care implementation progress in Uganda

The Pan African Medical Journal, 2014
INTRODUCTION: Prematurity is the leading cause of newborn death in Uganda, accounting for 38% of the nation's 39,000 annual newborn deaths. Kangaroo mother care is a high-impact; cost-effective intervention that has been prioritized in policy in Uganda ...
Patrick Aliganyira, Kate Kerber, Karen Davy, Nathalie Gamache, Namaala Hanifah Sengendo, Anne-Marie Bergh   +5 more
doaj   +1 more source

The immune consequences of preterm birth

Frontiers in Neuroscience, 2013
Preterm birth occurs in 11% of live births globally and accounts for 35% of all newborn deaths. Preterm newborns have immature immune systems, with reduced innate and adaptive immunity; their immune systems may be further compromised by various factors ...
Jacqueline M Melville, Timothy J M Moss, Timothy J M Moss   +2 more
doaj   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Association of various postnatal risk factors with progression of retinopathy of prematurity (ROP) in preterm neonates: A case-control study

Journal of Family Medicine and Primary Care
Retinopathy of prematurity (ROP) is a complex disease of the developing retinal vasculature in infants born prematurely and is the leading preventable cause of childhood blindness worldwide. Multiple factors play a significant role in the pathogenesis of
Alisha Gaba, Harijot Singh, Rajwinder Kaur   +2 more
doaj   +1 more source

PRETERM LABOUR:

The Professional Medical Journal, 2017
Objectives: (1) to find out of aetiological factors of preterm labour. (2) To makea proposed remedy for prevention of preterm lobour. Material and Methods: This study wascarried out at Independent University Hospital. This is located at richly populated area ofFaisalabad, providing health care facilities to poor socioeconomic group.
Tasneem Azher, Iram Aslam, Saadia Bano, Uzma Shahzad   +3 more
openaire   +2 more sources