Results 161 to 170 of about 6,044,805 (317)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Prevalence of and risk factors for FIV and FeLV infection in two shelters in the United Kingdom (2011–2012)

, 2017
Jenny Stavisky, Rachel Dean, Michael Henry Molloy   +2 more
openalex   +2 more sources

Prevalence and Clinical Characteristics of Local Allergic Rhinitis to House Dust Mites [PDF]

, 2017
Chang‐Gyu Jung, Ji-Ho Lee, Ga‐Young Ban, Hae‐Sim Park, Yoo Seob Shin   +4 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Implementation and Operational Research: Active Referral of Children of HIV-Positive Adults Reveals High Prevalence of Undiagnosed HIV

, 2016
Anjuli D. Wagner, Cyrus Mugo, Irene Njuguna, Elizabeth Maleche‐Obimbo, Kenneth Sherr, Irene Inwani, James P. Hughes, Dalton Wamalwa, Grace John‐Stewart, Jennifer A. Slyker   +9 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Prevalence of Oral Mucosal Lesions and Relation to Serum Cotinine Levels—Findings from a Cross-Sectional Study in South Africa [PDF]

, 2020
Carla Daniele Nascimento Pontes, Usuf Chikte, Faheema Kimmie‐Dhansay, Rajiv T. Erasmus, André Pascal Kengne, Tandi E. Matsha   +5 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Saw-Tooth Cardiomyopathy

JACC: Case Reports, 2020
Pablo Garcia-Pavia, MD, PhD, Fernando Dominguez, MD, PhD   +1 more
doaj   +1 more source

Prevalent [PDF]

, 2020
openaire   +1 more source