Results 231 to 240 of about 646,755 (265)

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Development and Validation of a One‐Dimensional Finite Difference Simulation Scheme for Polymer Laser Powder Bed Fusion with Application to the Effect of the Inter Layer Time

Advanced Engineering Materials, EarlyView.
The study presents an efficient simulation approach for the polymer laser powder bed fusion process polymers process, validated with polyamide 12, polyamide 6, and polyetherketoneketone. It shows that inter layer time affects part density, with 90s yielding dense parts.
Claas Bierwisch, Bastien Dietemann, Moritz Grünewald, Christian Schlör, Johannes Rudloff   +4 more
wiley   +1 more source

Icephobic Gradient Polymer Coatings Coupled with Electromechanical De‐icing Systems: A Promising Ice Repellent Hybrid System

Advanced Engineering Materials, EarlyView.
A hybrid system for de‐icing made of gradient polymer coatings, deposited on aluminum coupled with an electromechanical system, is demonstrated as an effective and durable strategy for reducing drastically ice adhesion. The system is capable of detaching ice blocks over the coating in less than 1 s, regardless of the ice type and covered area ...
Gabriel Hernández Rodríguez, Giulia Gastaldo, Luca Stendardo, Younes Rafik, Jason Pothin, Marc Budinger, Carlo Antonini, Valérie Pommier‐Budinger, Anna Maria Coclite   +8 more
wiley   +1 more source

Non‐Destructive and Mechanical Characterization of the Bond Quality of Co‐Extruded Titanium‐Aluminum Profiles

Advanced Engineering Materials, EarlyView.
This study investigates the bond quality of co‐extruded aluminum–titanium hybrid profiles, focusing on the lateral angular co‐extrusion (LACE) process. It examines how heat treatments (HT) affect intermetallic phase formation, bond strength, and material properties.
Norman Mohnfeld, Ahmed Dewidar, Karim Qarbi, Hendrik Wester, Florian Patrick Schäfke, Alexej Verschinin, Hans Jürgen Maier, Sebastian Barton, Christian Klose, Johanna Uhe   +9 more
wiley   +1 more source

Bioinspired Design of Isotropic Lattices with Tunable and Controllable Anisotropy

Advanced Engineering Materials, EarlyView.
This study introduces nested isotropic lattices, integrating architectural elements like nesting orders and orientations inspired by bioarchitectures. The design enables tunable anisotropy across nine mono‐nest and twenty multi‐nest lattices with 252 parametric variations, demonstrating transitions from shear‐ to tensile‐compression‐dominant behaviors ...
Ramalingaiah Boda, Biranchi Panda, Shanmugam Kumar   +2 more
wiley   +1 more source

Development of a Novel Processing Route for Dispersoid/Precipitation‐Strengthened High Conductive Copper Alloys by Using Metalized Nanoceramics in Additive Manufacturing

Advanced Engineering Materials, EarlyView.
This study explores a process chain to produce dispersoid‐strengthened CuCr1Zr for applications requiring high strength and conductivity. Using gas‐atomized powder and copper‐plated alumina nanoparticles, additive manufacturing is performed via powder bed based additive manufacturing with green and red lasers, followed by heat treatment.
Heinrich von Lintel, Abdelrahman Elsayed, Lukas Mielewczyk, Katja Eichmann, Julia Grothe, Ulrich Krupp, Avinash Hariharan, Katrin Jahns   +7 more
wiley   +1 more source

A Perspective on Powder Metallurgy and Additive Manufacturing of High‐Nitrogen Alloyed Stainless Steels

Advanced Engineering Materials, EarlyView.
This perspective article explores an innovative powder metallurgical approach to producing high‐nitrogen steels by utilizing a mixture of stainless steel and Si3N4. This mixture undergoes hot isostatic pressing followed by direct quenching. The article also examines adapting this method to laser powder bed fusion (PBF‐LB/M) to overcome nitrogen ...
Louis Becker, Felix Radtke, Jonathan Lentz, Simone Herzog, Christoph Broeckmann, Sebastian Weber   +5 more
wiley   +1 more source