Results 71 to 80 of about 1,654,926 (292)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prevalence of Child Sexual Abuse in Spain: A Survey Study

European Journal of Psychology Applied to Legal Context, 2023
Background/aim: Child sexual abuse (CSA) is a pervasive issue that affects children and adolescents worldwide, and Spain is no exception. Despite its high impact, there is a lack of comprehensive data on the prevalence of CSA in Spain. This study aims to
David Pineda, Peter Muris, Ana Martínez-Martínez, José A. Piqueras   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea

Clinical Ophthalmology, 2020
Cynthia Matossian,1 Xue Song,2 Ishveen Chopra,2 Amy Sainski-Nguyen,2 Abayomi Ogundele3 1Matossian Eye Associates, Doylestown, PA, USA; 2Outcomes Research, IBM Watson Health, Cambridge, MA, USA; 3Medical Affairs, Sun Pharmaceutical Industries, Inc ...
Matossian C, Song X, Chopra I, Sainski-Nguyen A, Ogundele A   +4 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Point Prevalence (PP), Period Prevalence Rate (PPR), Recurrence Rate (RR) Incidence Rate (IR) of Current Depressive Symptoms by Explanatory Variables among HIV-positive Participants.

, 2016
Point Prevalence (PP), Period Prevalence Rate (PPR), Recurrence Rate (RR) Incidence Rate (IR) of Current Depressive Symptoms by Explanatory Variables among HIV-positive Participants.
Sandra Gardner (826097), Sean B. Rourke (283714), Eleanor Boyle (826096), John Cairney (2826092), Evan J. Collins (2826095), Stephanie K. Y. Choi (826095), Jean Bacon (2826098)   +6 more
core   +1 more source

Estimating Plasmodium falciparum transmission rates in low-endemic settings using a combination of community prevalence and health facility data. [PDF]

, 2012
As some malaria control programs shift focus from disease control to transmission reduction, there is a need for transmission data to monitor progress.
Yemane Berhane, Joshua Yukich, Yukich Joshua, Eisele Thomas P., Lemma, Seblewengel, Bennett, Adam, Joseph Keating, Thomas P. Eisele (143002), Keating Joseph, Briët, O., Olivier Briët, Berhane Yemane, Seblewengel Lemma, Briët, Olivier, Yukich, J., Smith, T., Adam Bennett (142993), Seblewengel Lemma (142997), Bretscher, M. T., Bennett Adam, Lemma Seblewengel, Joshua Yukich (44606), Bretscher, Michael T, Keating, Joseph, Thomas P. Eisele, Smith Thomas, Berhane, Yemane, Thomas Smith (74383), Bretscher Michael T., Eisele, Thomas P, Yukich, Joshua, Thomas Smith, Lemma, S., Berhane, Y., Michael T. Bretscher, Adam Bennett, Bennett, A., Michael T Bretscher, Michael T. Bretscher (134912), Yemane Berhane (87923), Briët Olivier, Eisele, T. P., Olivier Briët (142988), Smith, Thomas, Thomas P Eisele, Keating, J., Joseph Keating (55099)   +46 more
core   +1 more source

Comparison of crude prevalence rate (CPR) and true prevalence rate (TPR) of caries, calculus and deciduous molar dentine exposure between male and female children.

, 2023
Comparison of crude prevalence rate (CPR) and true prevalence rate (TPR) of caries, calculus and deciduous molar dentine exposure between male and female children.
Christoph Kurzmann (14581236), Marlon Bas (14581233), Katharina Rebay-Salisbury (14581245), Doris Pany-Kucera (14581242), Fabian Kanz (645181), John Willman (14581239)   +5 more
core   +1 more source

Prevalence Rates of Mental Disorders in Chilean Prisons

PLoS ONE, 2013
High rates of mental disorders have been reported for prison populations worldwide, particularly in low- and middle-income countries (LMICs). The present study aimed to establish prevalence rates of mental disorders in Chilean prisoners.A nationwide random sample of 1008 prisoners was assessed in 7 penal institutions throughout Chile.
Mundt, AP, Alvarado, R, Fritsch, R, Poblete, C, Villagra, C, Kastner, S, Priebe, S   +6 more
openaire   +5 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source