Results 201 to 210 of about 7,991,089 (298)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Exercise to prevent falls in older adults: an updated systematic review and meta-analysis

British Journal of Sports Medicine, 2016
C. Sherrington, Z. Michaleff, N. Fairhall, S. Paul, A. Tiedemann, J. Whitney, R. Cumming, R. Herbert, J. Close, S. Lord   +9 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers. [PDF]

Sci Adv
Gallego-Rudolf J, Wiesman AI, Yakoub Y, Zetterberg H, Blennow K, Baillet S, Villeneuve S, PREVENT-AD Research Group.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Host DNases prevent vascular occlusion by neutrophil extracellular traps

Science, 2017
M. Jiménez-Alcázar, C. Rangaswamy, R. Panda, Josephine Bitterling, Yashin J. Simsek, Andy T. Long, R. Bilyy, V. Krenn, C. Renné, T. Renné, S. Kluge, U. Panzer, Ryushin Mizuta, H. Mannherz, D. Kitamura, M. Herrmann, M. Napirei, T. Fuchs   +17 more
semanticscholar   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Evaluating algorithmic fairness in the performance of the AHA PREVENT equations versus pooled cohort equations among single-race and multiracial populations. [PDF]

Am J Prev Cardiol
Bacong AM, Yan X, Huang Q, Husby H, Li J, Kenkare P, Rodriguez F, Palaniappan L.   +7 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Florence Nightingale's Contemporary Legacy for Patient Safety: Implications for Nursing and Public Health. [PDF]

Nurs Inq
Alcantara EL, Silva CPGD, Almeida Filho AJ, Cavalcanti HCN, Duarte SDCM, Santos TCF.   +5 more
europepmc   +1 more source