Results 71 to 80 of about 3,147,199 (247)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Breast cancer risk status influences uptake, retention and efficacy of a weight loss programme amongst breast cancer screening attendees: two randomised controlled feasibility trials

BMC Cancer, 2019
Background Excess body weight and sub-optimal lifestyle are modifiable causes of breast cancer and other diseases. There is little evidence that behaviour change is possible within screening programmes and whether this is influenced by prior knowledge of
Michelle Harvie, Mary Pegington, David French, Grace Cooper, Sarah McDiarmid, Anthony Howell, Louise Donnelly, Helen Ruane, Katharine Sellers, Philip Foden, D. Gareth Evans   +10 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

KUR’ÂN’A GÖRE ALLAH YOLUNDAN ALIKOYMA (es-SADD ‘AN SEBÎLİLLAH)

İslam Medeniyeti Araştırmaları Dergisi, 2016
Tarih her daimhak ile bâtılın mücadelesine tanıklık etmiştir. Bu mücadelede hak tarafını peygamberlerve onlara iman edenler; bâtıl tarafını ise vahye karşı çıkan şeytan, inkârcılarve özellikle inkârcı toplumların önde gelen eşraf tabakası oluşturmuştur ...
İbrahim Yıldız
doaj  

Designing and Conducting an Injury Study in Amateur Badminton Players

Applied Sciences
This study aims to examine sports injuries among amateur badminton players engaged in recreational activities, establishing a foundation for developing effective injury prevention and training programs.
Jin-Wook Jeon, Seung-Taek Lim, Ji-Hoon Cho   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Schools′ cafeteria status: Does it affect snack patterns? a qualitative study

International Journal of Preventive Medicine, 2013
Background: The aim of this study was to evaluate patterns of students′ snacks habits regarding to their schools′ cafeteria status in Tehran by focus group discussion (FGD) technique.
Fatemeh Esfarjani, Fatemeh Mohammadi, Roshanak Roustaee, Majid Hajifaraji   +3 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Preventing Preventative Health

Online Journal of Health Ethics, 2010
With the Earth’s human population estimated to exceed 10 billion by 2050, the now globalised community has some serious discussions involving the upcoming, necessary transition to sustainable habitation and preventative healthcare. This paper examines the social and economic structures preventing this transition at individual, national and ...
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source