A method for assessing the success and failure of community-level interventions in the presence of network diffusion, social reinforcement, and related social effects [PDF]
Prevention and intervention work done within community settings often face unique analytic challenges for rigorous evaluations. Since community prevention work (often geographically isolated) cannot be controlled in the same way other prevention programs
Dombrowski, Kirk +5 more
core +2 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
COVID-19 impact on HIV PrEP uptake and retention at selected health facilities in Eswatini
Background: Oral pre-exposure prophylaxis (PrEP) uses antiretroviral medication to reduce HIV risk in HIV-negative individuals. Despite its effectiveness, global uptake faces policy and accessibility challenges.
Musa B. Ginindza +2 more
doaj +1 more source
The negative effect of financial constraints on planning prevention activities: some evidence from the Italian experience [PDF]
This study was aimed to assess the association between regional financial deficits and Recovery Plans and the quality of the 702 projects developed by the Italian Regions within the National Prevention Plan 2010-13.
D'ANDREA, ELVIRA +5 more
core +1 more source
Hematopoietic (stem) cells—The elixir of life?
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Survey of AIDS Prevention Funders: Which Programs Are Funded, and Why?, A? [PDF]
This survey of foundations across the United States asked questions about the amount of money they spend on AIDS and HIV prevention, the types of prevention projects and populations their grants served, and the sources of AIDS information used by the ...
Joshua Schechtel
core
The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Patient autonomy and disclosure of material information about hospital-acquired infections
Sorin Hostiuc,1 Arthur-Jozsef Molnar,2 Alin Moldoveanu,3 Maria Aluaş,4 Florica Moldoveanu,3 Iuliana Bocicor,2 Maria-Iuliana Dascalu,5 Elisabeta Bădilă,6 Mihaela Hostiuc,6 Ionut Negoi7 1Department of Legal Medicine and Bioethics, Carol Davila University ...
Hostiuc S +9 more
doaj

