Results 101 to 110 of about 5,972,901 (291)
Preventing Suicide in Colorado: Progress Achieved & Goals for the Future [PDF]
, 2009 This 2009 report, issued jointly by Mental Health America of Colorado and The Colorado Trust, updates both the state's 1998 Suicide Prevention and Intervention Plan to address Colorado's historically high suicide rate, as well as The Trust's 2002 report ...
Anita Coen +3 more
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
BCG vaccine and pulmonary tuberculosis
Vaccine Research, 2017 Tuberculosis (TB) is one of the most important public health problems in the world and has been declared as a global emergency by the World Health Organization (WHO) in 1993.
SH Tafreshi
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
REPRESENTAÇÕES DE UM GRUPO DE DOCENTES SOBRE DROGAS: ALGUNS ASPECTOS
Ensaio Pesquisa em Educação em CiênciasO abuso de drogas é atualmente um grave problema de saúde pública e a escola básica deve contribuir com a sua prevenção. O objetivo do trabalho foi identificar as representações sociais dos professores de um grupo de professores de educação básica sobre ...
Cláudia Virginia Galindo Cavalcante +5 more
doaj +1 more source
SCREENING OF CHRONIC KIDNEY DISEASE IN TAJIKISTAN RESIDENTS
Паёми Сино, 2019 Objective: Assessment of the prevalence causes and risk factors for the development of chronic kidney disease (CKD) in the Republic of Tajikistan Methods: Screening of CKD and risk factors for its development among 374 persons in the course of ...
M.K. GULOV, S.M. ABDULLOEV
doaj +1 more source
Current Trends in Child Abuse Prevention and Fatalities: The 2000 Fifty State Survey [PDF]
, 2002 This survey takes a closer look at two pressing needs. The first is the important role of prevention, specifically at the most effective prevention programs and how they are funded.
Ching-Tung Wang +3 more
core
Preventing Preventative Health
Online Journal of Health Ethics, 2010 With the Earth’s human population estimated to exceed 10 billion by 2050, the now globalised community has some serious discussions involving the upcoming, necessary transition to sustainable habitation and preventative healthcare. This paper examines the social and economic structures preventing this transition at individual, national and ...
openaire +3 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source