Results 211 to 220 of about 462,528 (255)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

When a fall leads to a hospital emergency department visit: a focus group study on factors influencing the adoption of falls prevention measures. [PDF]

BMJ Open
Reeck N, Völkel A, Mammes M, Urbahn-Schiefer D, Reineking B, Brushinski E, Stuckenschneider T, Zieschang T, Brütt AL.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Falls in older adults in sub-Saharan Africa: an urgent call for rehabilitation-centred action. [PDF]

BMJ Public Health
Ghassi HT, Muntessu Nsangou DL, Buh FC, Anwar F.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

History and Current Status of the HIV/AIDS Supporting Network System. [PDF]

Jugan Geongang Gwa Jilbyeong
Cho S, Kim K, Han S, Hyun J, Yu J.
europepmc   +1 more source

Best practice primary and secondary preventative interventions in chronic disease in remote Australia [PDF]

, 2018
Battye, Kristine, Schmidt, Barbara, Smith, Janie Dade   +2 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Global solidarity in genomic surveillance improves early detection of acute respiratory virus threats. [PDF]

Nat Commun
de Jong SPJ, Nichols BE, de Ruijter A, Parker E, Mitesser V, Happi C, de Jong MD, Han AX, Russell CA.   +8 more
europepmc   +1 more source

The Boston University Pre-Law Review Volume XXIV Issue 1, Fall 2014 [PDF]

, 2014
Adeosun, Lola, Amatuzzi, Ana Paula, Bailey, Evan, Boots, Aleksandra, Bourne, Jennifer, Broe, Patricia, Cavena, Bill, Chinni, Manasa, Dolci, Paige, Downs, Carolyn, Fikar, Hannah, Finnegan, Cassandra, Gartsbeyn, Cheryl, Goldberg, Natalie, Harper, Catherine, Keuler, Andrew, Knox, Ryan, LeCates, Victoria, Marcus, Alexandra, Mazzarelli, India, Narula, Neha, Park, Jung Hyun, Patel, Disha, Peluso, Katherine, Pico, Merissa, Pollack, Yvette, Ramesh, Shreya, Rollins, Daniel, Silverman, Elizabeth, St. Laurent, Benjamin, Sy, Stella, Viroja, Janki, Willis, Catherine, Yim, Martin   +33 more
core   +1 more source