Results 61 to 70 of about 54,982 (232)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Can we depend on case management to prevent re-establishment of P. falciparum malaria, after local interruption of transmission?

Epidemics, 2012
Recent declines in malaria burden in many parts of the world have prompted consideration of how interruption of Plasmodium falciparum transmission could be maintained, if achieved, and notably whether large-scale vector control could be replaced with surveillance. This information is essential for elimination feasibility assessments and planning.
Crowell, V., Hardy, D., Briët, O., Chitnis, N., Maire, N., Smith, T.   +5 more
openaire   +3 more sources

Protocol for a stepped-wedge, cluster randomized controlled trial of the LifeSpan suicide prevention trial in four communities in New South Wales, Australia

Trials, 2020
Background Despite increasing investment in suicide prevention, Australian suicide rates have increased steadily in the past decade. In response to growing evidence for multicomponent intervention models for reducing suicide, the LifeSpan model has been ...
Fiona Shand, Michelle Torok, Nicole Cockayne, Philip J. Batterham, Alison L. Calear, Andrew Mackinnon, Dean Martin, Isabel Zbukvic, Katherine Mok, Nicola Chen, Lauren McGillivray, Matthew Phillips, Henry Cutler, Brian Draper, Grant Sara, Helen Christensen   +15 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Re-establishing safer medical-circumcision-integrated initiation ceremonies for HIV prevention in a rural setting in Papua New Guinea. A multi-method acceptability study

PLOS ONE, 2017
Efforts to stem the spread of Human Immunodeficiency Virus (HIV) in Papua New Guinea (PNG) are hampered by multiple interrelated factors including limited health services, extreme diversities in culture and language and highly prevalent gender inequity, domestic violence and poverty.
Clement Morris Manineng, David MacLaren, Maggie Baigry, Emil Trowalle, Reinhold Muller, Andrew Vallely, Patrick Gesch, Francis Hombhanje, William John McBride   +8 more
openaire   +5 more sources

A review of existing studies reporting the negative effects of alcohol access and positive effects of alcohol control policies on interpersonal violence

Frontiers in Public Health, 2015
Alcohol consumption often leads to elevated rates of violence yet alcohol access policies continue to relax across the globe. Our review establishes the extent alcohol policy can moderate violent crime through alcohol availability restrictions.
Jessica Laura Fitterer, Trisalyn A Nelson, Timothy eStockwell   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Epidemiological and clinical aspects of diagnosis, treatment and prophylaxis of imported malaria cases in Russian Federation

Терапевтический архив, 2020
Actually one of the main tasks of health workers in the field of the tropical diseases prevention (malaria) is early detection of malaria imported cases and efficacious treatment.
A. K. Tokmalaev, A. M. Baranova, V. V. Maleev   +2 more
doaj  

The prevention and control of dengue after Typhoon Haiyan

Western Pacific Surveillance and Response, 2015
Objective: Many of the areas in the Philippines affected by Typhoon Haiyan are endemic for dengue; therefore, dengue prevention was a priority in the initial post-disaster risk assessment. We describe the dengue prevention and response strategies applied
Charito Aumentado, Boyd Roderick Cerro, Leonido Olobia, Lyndon Lee Suy, Aldrin Reyes, Pahalagedera HD Kusumawathie, Maria Sagrado, Julie Lyn Hall, Rabindra Abeyasinghe, Alice Ruth Foxwell, Lasse S Vestergaard   +10 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source