Results 51 to 60 of about 40,858 (238)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Establishing and applying an adaptive framework for imported malaria: a field practice in Anhui Province, China from 2012 to 2022

BMC Public Health
Background Anhui Province is currently facing an increase in imported malaria cases as a result of globalization and international travel. In response, Anhui Province has implemented a comprehensive adaptive framework to effectively address this threat ...
Tao Zhang, Xian Xu, Bowen Liu, Duoquan Wang, Xiangguang Ye, Jingjing Jiang, Shuqi Wang, Xiaofeng Lyu, Chen Yu, Cuicui Tian, Zijian Liu, Xuechun Lu, Shizhu Li, Weidong Li   +13 more
doaj   +1 more source

The U.S. Government's Global Health Policy Architecture: Structure, Programs and Funding [PDF]

, 2009
Provides an overview of the history, scope, and role of U.S. engagement in global health, including funding; statutes, authorities, and policies; agencies involved; major initiatives; and countries with U.S.

core  

Efficacious, effective, and embedded interventions: Implementation research in infectious disease control [PDF]

, 2008
Background: Research in infectious disease control is heavily skewed towards high end technology; development of new drugs, vaccines and clinical interventions.
A Garba, A Meyer, A Werner, AM Chinbuah, BR Flay, BR Flay, C Lengeler, Centre for Public Health Research, D Fixsen, D Sanders, Daniel D Reidpath, EA McCarthy, FN Binka, FN Binka, Franco Pagnoni, H Guyatt, H Pearson, H Saetren, Hashim Ghalib, J Okrah, JA DiMasi, JHF Remme, JRMA Schellenberg, K Guldbrandsson, LA Bero, M Chopra, M Eccles, M Moran, MR Bhatia, O Bhattacharyya, Pascale Allotey, PDH Molyneux, PL Alonso, R Grol, RE Glasgow, Roll Back Malaria, World Health Organization, UNICEF, TL Gary, William C Skelly, Z Obermeyer   +38 more
core   +4 more sources

Additional file 1 of Transfusion-induced Plasmodium falciparum malaria in a beta thalassaemia patient during the prevention of re-establishment phase in Sri Lanka

, 2021
Additional file 1: Table S1. Data on beta thalassaemia patient diagnosed with malaria.
Chulasiri, Pubudu, Ranaweera, Prasad, Sudarshan, Ponnuthurai, Jayasinghe, Maya, Harishchandra, Jeevani, Gunasekera, Kumudu, Vitharana, Harshini, Silva, Priyanganie, Ringwald, Pascal, Fernandopulle, Rohini, Mendis, Kamini, Fernando, Deepika   +11 more
openaire   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

History of malaria control in Rwanda: implications for future elimination in Rwanda and other malaria-endemic countries

Malaria Journal, 2020
Background Malaria was first reported in Rwanda in the early 1900s with significant heterogeneity and volatility in transmission over subsequent decades.
Corine Karema, Shawn Wen, Abigail Sidibe, Jennifer L. Smith, Roly Gosling, Emmanuel Hakizimana, Marcel Tanner, Abdisalan M. Noor, Allison Tatarsky   +8 more
doaj   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

msp1, msp2, and glurp genotyping to differentiate Plasmodium falciparum recrudescence from reinfections during prevention of reestablishment phase, Sri Lanka, 2014–2019

Malaria Journal
Background Sri Lanka after eliminating malaria in 2012, is in the prevention of re-establishment (POR) phase. Being a tropical country with high malariogenic potential, maintaining vigilance is important.
Kumudunayana T. Gunasekera, Risintha G. Premaratne, Shiroma M. Handunnetti, Jagathpriya Weerasena, Sunil Premawansa, Deepika S. Fernando   +5 more
doaj   +1 more source