Results 181 to 190 of about 11,113,149 (315)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

HIV seroprevalence surveys: impetus for preventive activities.

American Journal of Public Health, 1991
L. Novick
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Increasing the capacity of community managed organisations to provide chronic disease preventive care to people with a mental health condition: protocol for a cluster-randomised controlled trial. [PDF]

BMC Public Health
Love S, Fehily C, Ampofo A, Ryall J, Marasha F, Latter J, Lodge S, Jackson B, Campbell E, Oldmeadow C, Wynne O, Orr M, Govindasamy S, Bowman J.   +13 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

The curative-to-preventive perspective shift of medical students through community dementia programs: a qualitative study based on transformative learning theory. [PDF]

Front Public Health
Huang R, Zhu Z, He M, Cai P, Wang R, Ran L, Yang X, Zhang B.   +7 more
europepmc   +1 more source

Using nurses for preventive activities with computer assisted follow up: a randomised controlled trial.

British medical journal, 1989
J. Robson, K. Boomla, S. Fitzpatrick, A. J. Jewell, Jane Taylor, J. Self, M. Colyer   +6 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Perceptions of Fall Prevention and Engagement in Social Prescribing Activities Among Older Adults: A Cross-Sectional Study in Portugal. [PDF]

Healthcare (Basel)
Matos C, Baixinho CR, Alarcão V, Henriques MA, Ferreira RO, Nascimento T, Arriaga M, Alves T, Nogueira P, Costa A.   +9 more
europepmc   +1 more source

[Preventive activities in women]. [PDF]

Aten Primaria, 2014
López García-Franco A, Arribas Mir L, del Cura González I, Bailón Muñoz E, Iglesias Piñeiro MJ, Gutiérrez Teira B, Landa Goñi J, Ojuel Solsona J, Fuentes Pujol M, Alonso Coello P, Grupo de la Mujer del PAPPS.   +10 more
europepmc   +1 more source