Results 241 to 250 of about 11,113,149 (315)

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

The impact of intermittent preventive treatment for malaria on school absenteeism among primary school-aged children in Handeni District Council, Tanzania: quasi-experimental study. [PDF]

Malar J
Kidumule FM, Omary H, Zacharia A, Mringo B, Shonde A, Ngasala B, Ottaru TA.   +6 more
europepmc   +1 more source

OCG response to cholera in Haiti 2010-11 [PDF]

, 2011
Bergeri, Isabel, Kampmueller, Sabine, Vienna Evaluation Unit   +2 more
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Knowledge and Preventive Practices Regarding Diabetes Mellitus Among Non-Diabetic Adults in Kamrup Rural District of Assam: A Cross-Sectional Study. [PDF]

Cureus
Hazarika D, Khan I, Lahkar M.
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

The Impact of Public Health Interventions on the Frequency and Duration of Hospitalisations Among Seniors in Poland-An Analysis Covering the Years 2017-2018. [PDF]

J Clin Med
Kwiatkowska K, Pajewska M, Partyka O, Czerw A, Charkiewicz D, Strzępek Ł, Curyło M, Zawadzka M, Urbaniak M, Sygit K, Porada S, Gąska I, Kaczmar E, Drobnik J, Pobrotyn P, Waśko-Czopnik D, Sowiński T, Grata-Borkowska U, Tejza K, Bandurska E, Ciećko W, Grochans E, Cybulska AM, Schneider-Matyka D, Borzuchowska M, Kamecka K, Kozlowski R.   +26 more
europepmc   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source