Results 51 to 60 of about 782,060 (307)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Communication skills of a local general practitioner in conducting preventive counseling (methodological aspect)

Кардиоваскулярная терапия и профилактика, 2023
The article considers the problem of developing communicative competence of local general practitioners in preventive counseling. The study showed that the process of preventive counseling is an integration of medical diagnostic, preventive and ...
S. Yu. Astanina, A. M. Kalinina, R. N. Shepel, E. A. Derinova, N. A. Mikhailova, O. M. Drapkina   +5 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

500 Cities Project: Local Data for Better Health 2014 [PDF]

, 2016
The 500 Cities Project-Local Data for Better Health-is a collaboration among the Robert Wood Johnson Foundation, the CDC Foundation, and the Centers for Disease Control and Prevention (CDC), whose purpose is to provide high quality small area estimates ...
Center for Disease Control and Prevention, Robert Wood Johnson Foundation   +1 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Threats Management Throughout the Software Service Life-Cycle

, 2014
Software services are inevitably exposed to a fluctuating threat picture. Unfortunately, not all threats can be handled only with preventive measures during design and development, but also require adaptive mitigations at runtime.
Gjære, Erlend Andreas, Meland, Per Håkon   +1 more
core   +2 more sources

A mixed methods approach to evaluating community drug distributor performance in the control of neglected tropical diseases [PDF]

, 2016
BACKGROUND: Trusted literate, or semi-literate, community drug distributors (CDDs) are the primary implementers in integrated preventive chemotherapy (IPC) programmes for Neglected Tropical Disease (NTD) control.
A Wallace, AW Solomon, C Hanson, D Evans, EC Emukah, Fiona M. Fleming, FM Fleming, Fred Matovu, J Green, J Leslie, JA Wright, JC Okeibunor, JC Okeibunor, JH Kolaczinski, JH Kolaczinski, Joanne P. Webster, JS Dill, K Banek, KA Grepin, KL Leonard, Kristian S. Hansen, L Nkonki, M Callaghan, MA Bruijnzeels, MC Baker, MF Drummond, Ministry of Health, MN Katabarwa, MO Omedo, N Najnin, P Agyei-Baffour, P Akweongo, P Basinga, SC Francis, TK Ryman, UV Amazigo, V Wiseman, World Health Organisation, World Health Organisation, World Health Organization   +39 more
core   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

CAMPANHAS AUDIOVISUAIS DE PREVENÇÃO EM SST E O PERFIL DE AGRAVOS NO BRASIL: encontros e desencontros

Revista Trabalho, Política e Sociedade, 2020
This research have sought to add knowledge about which sectors and economic activities are prevailing or being neglected in public preventive campaigns in Safety and Health at Work.
Leo Vinicius Maia Liberato
doaj   +1 more source