Results 91 to 100 of about 4,835,037 (304)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: provider knowledge and acceptability. [PDF]

, 2011
Malaria in pregnancy (MiP) is associated with increased risks of maternal and foetal complications. The WHO recommends a package of interventions including intermittent preventive treatment (IPT) with sulphadoxine-pyrimethamine (SP), insecticide-treated ...
Smith Paintain Lucy, Nana A Afrah, Gifty D. Antwi, Daniel Chandramohan, Webster, Jayne, Antwi Gifty D., Amoako, Esther, Jones Caroline, Esther Amoako, Tagbor, Harry, Caroline Jones, Jones, Caroline, Greenwood, Brian, Brian Greenwood, Adjei, Rose O, Chandramohan Daniel, Gifty D Antwi, Rose O. Adjei, Greenwood Brian, Smith Paintain, Lucy, Afrah Nana A., Afrah, Nana A, Adjei Rose O., Antwi, Gifty D, Chandramohan, Daniel, Tagbor Harry, Harry Tagbor, Jayne Webster, Lucy Smith Paintain, Rose O Adjei, Nana A. Afrah, Webster Jayne, Amoako Esther   +32 more
core   +2 more sources

Occupational health services in Poland during the COVID-19 pandemic

International Journal of Occupational Medicine and Environmental Health
Objectives This publication analyses the activities of physicians and occupational medicine units in Poland during this period. Material and Methods The analysis of the number of physicians and units of occupational medicine and the preventive and ...
Andrzej Marcinkiewicz, Marta Szkiela
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Preventive medical care in remote Aboriginal communities in the Northern Territory: a follow-up study of the impact of clinical guidelines, computerised recall and reminder systems, and audit and feedback [PDF]

, 2003
Background Interventions to improve delivery of preventive medical services have been shown to be effective in North America and the UK. However, there are few studies of the extent to which the impact of such interventions has been sustained, or of the
Bailie, Ross S., Robinson, Gary, Bailie, Ross Stewart, D'abbs, P H, Togni, Samantha, d'Abbs, Peter H.N., d'Abbs, Peter, Togni, Samantha J., Si, Damin   +8 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Romancing the Carer - Intimate Relationships and Family Caring

, 2017
The topic of sexuality and romantic intimacy is not an easy one for many to discuss; in particular is it is often seen as secondary to the difficulties being faced in other aspects of life and in the relationship.
Care Alliance Ireland
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Recommendation from the Community Preventive Services Task Force for Use of Collaborative Care for the Management of Depressive Disorders

, 2012
The Community Preventive Services Task Force recommends collaborative care for management of depressive disorders, based on strong evidence of effectiveness in improving depression symptoms, adherence to treatment, response to treatment, and remission ...
Community Preventive Services Task Force, N/A
core   +1 more source