Results 131 to 140 of about 6,492,071 (353)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Tobacco Treatment Disparities Among California Medicaid Members With and Without Chronic Disease Who Smoke

AJPM Focus
Introduction: People who are covered by Medicaid have a higher smoking prevalence than the general population and are at an increased risk for tobacco-related disease, a major driver of Medicaid costs.
Nan Wang, PhD, Melanie S. Dove, ScD, Cindy V. Valencia, PhD, Elisa K. Tong, MD   +3 more
doaj   +1 more source

Preventive health care and payment systems to providers [PDF]

Prevention has been a main issue of recent policy orientations in health care. This renews the interest on how different organizational designs and the definition of payment schemes to providers may affect the incentives to provide preventive health care.
Pedro P. Barros, Xavier Martinez-Giralt
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Diagnosis and treatment option for dental caries using photographs a study among undergraduate students

Journal of Indian Association of Public Health Dentistry, 2013
Background: Visual examination is the basis for diagnosing the carious lesions in clinical and field setting. Aims and Objectives: To determine the accuracy of identifying the carious lesions at different stages and their treatment options using ...
K M Shwetha, Pushpanjali Krishnappa
doaj  

Comparing the efficacy of different maintenance intervals on preventing disease recurrence in patients with a history of periodontal treatment

Journal of Pharmacy and Bioallied Sciences
Background: Scheduled maintenance appointments after periodontal treatment are very much critical for the success of the treatment. This is necessary for patients seeking to prevent disease recurrence and maintain oral health.
Kiran K Ganji, Mohammad K Alam, Mohammed Ali Alkhwaitm, Kholood A S Al-Hammad, Sherif Sultan   +4 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Good care practices can mitigate the negative effects of poverty and low maternal schooling on children's nutritional status [PDF]

This study uses data from a representative survey of households with preschoolers in Accra, Ghana to (1) examine the importance of care practices for children's height-for-age z-scores (HAZ); and (2) identify subgroups of children for whom good maternal ...
Armar-Klemesu, Margaret, Levin, Carol E., Maxwell, Daniel G., Morris, Saul Sutkover, Ruel, Marie T.   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Resources and activities of voivodeship occupational medicine centers in Poland during the COVID-19 pandemic

Medycyna Pracy
Background Voivodeship Occupational Medicine Centres (VOMC), being higher-level units towards basic units providing preventive care for employees in Poland, play a consultative, appeal, supervisory and registration role towards them.
Andrzej Marcinkiewicz, Paweł Wdówik, Weronika Burdelak, Karolina Marcinkiewicz   +3 more
doaj   +1 more source