Results 81 to 90 of about 400,482 (297)
Frontiers in Aging Neuroscience, 2014 There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical ...
Jane S Paulsen +17 more
doaj +1 more source
The Built Environment and Physical Activity: What Is the Relationship? [PDF]
, 2007 Synthesizes research on how the built environment -- recreational resources, land use mix and connectivity, presence of sidewalks and streetlights, and community environment -- affects residents' physical activity and health across ...
Claudia H. Williams
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Payesh, 2014 Objective (s): The purpose of this study was to evaluate the impact of an educational package on attitude, self efficacy and tobacco use preventive behaviors of adolescents in Zarandieh, Iran. Methods: This was a quasi-experimental study.
Mahmood Karimy +3 more
doaj
Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury
Intensive Care Medicine Experimental, 2018 Background CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a massive cleavage and shedding of the most extracellular domains of CD31 into plasma, enhancing the ...
Quoc Thang Hoang +13 more
doaj +1 more source
Tropical Lymphedemas — Control and Prevention [PDF]
New England Journal of Medicine, 2012 Lymphedema in the tropics has two main causes: lymphatic filariasis caused by the parasitic nematode Wuchereria bancrofti, transmitted by mosquitoes, and podoconiosis, caused by microsilica particles from red-clay volcanic soil that enter the skin of the feet.
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The granule cell density of the dentate gyrus following administration of Urtica dioica extract to young diabetic rats [PDF]
, 2008 Urtica dioica L. Stinging nettle has long been known worldwide as a medicinal plant. To study the benefits of the nettle in diabetic encephalopathy, the granule cell density of the dentate gyrus of diabetic rats was studied following administration of ...
Fazeli, S.A. +4 more
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