Results 91 to 100 of about 2,021,702 (360)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Associations of SNPs of the ADIPOQ Gene with Serum Adiponectin Levels, Unstable Angina, and Coronary Artery Disease

Biomolecules, 2019
Adiponectin is encoded by the ADIPOQ gene and participates in the pathogenesis of cardiovascular and metabolic diseases. The goal of the study was to assess associations of rs17300539, rs266729, rs182052, rs2241766, and rs17366743 single nucleotide ...
Stepan Smetnev, Marina Klimushina, Vladimir Kutsenko, Anna Kiseleva, Nadezhda Gumanova, Alexander Kots, Olga Skirko, Alexandra Ershova, Elena Yarovaya, Victoria Metelskaya, Alexey Meshkov, Oksana Drapkina   +11 more
doaj   +1 more source

Plasmonic colored nanopaper: a potential preventive healthcare tool against threats emerging from uncontrolled UV exposure

Journal of Physics: Photonics, 2019
Preventive healthcare is crucial to hinder or delay the onset of disease, furthermore it contributes to healthy and productive lifestyles and saves resources allocated to public health.
Leydi Francisco-Aldana, E. Morales-Narváez   +1 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Impact of non-high-density lipoprotein cholesterol in mortality and cardiovascular events among middle-aged Russian men: 40 years ago and now

Рациональная фармакотерапия в кардиологии
Aim. To evaluate the non-high density lipoprotein cholesterol (non-HDL-C) predictive ability in relation to cardiovascular events, all-cause and cause-specific mortality and among middle-aged Russian men now and 40- years ago.Material and methods.
S. A. Shalnova, A. E Imaeva, Yu. A Balanova, V. A Kutsenko, A. V Kapustina, V. A Metelskaya, N. A Imaeva, B. M Nazarov, O. E Ivlev, E. B Yarovaya, O. M Drapkina   +10 more
doaj   +1 more source

NEW ORAL ANTICOAGULANTS: IS THAT PLAUSIBLE TO IMPLEMENT THE DATA FROM INTERNATIONAL TRIALS TO RUSSIAN POPULATION?

Кардиоваскулярная терапия и профилактика, 2015
Aim. To compare, in what extent are the patients with atrial fibrillation (AF), included into three large randomized clinical trials (RCT) of the new oral anticoagulants (NOAC), comparable with Russian patients with AF. Material and methods.
S. Yu. Martsevich, A. R. Navasardian, N. A. Zakharova, М. М. Lukianov   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

EXERCISE TESTS IN CARDIOLOGY: PAST, PRESENT AND FUTURE (PART I)

Кардиоваскулярная терапия и профилактика, 2015
The literary review is focused on diagnostics of coronary heart disease (CHD) with the use of the most common functional exercise tests. The benefits and the lacks are discussed of a variety of tests for suspected CHD. The results of longitude controlled
V. P. Voronina, N. V. Kisseleva, S. Yu. Martsevich   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source